Jul 02, 2019
  • Data presented again at European Academy of Neurology (EAN) congress show that baseline neurofilament light chain (NfL) levels can predict cognitive impairment and disability worsening in secondary progressive MS (SPMS) patients, supporting the use of blood NfL levels as a biomarker[1]
  • EXPAND data previously presented demonstrated Mayzent® (siponimod) has a meaningful benefit on cognitive processing speed with a 22.6% relative risk reduction versus placebo in SPMS patients with cognitive impairment[2]
  • In addition, EXPAND data suggested early treatment is important for better cognitive outcomes[2]
  • Novartis presented a total of 23 abstracts at EAN, emphasizing its strong multiple sclerosis (MS) portfolio with 11 abstracts
  • Also, Novartis presented data in multiple sclerosis on its investigational ofatumumab (OMB157) for relapsing forms of MS

Basel, July 2, 2019 - Novartis today presented data on cognition in multiple sclerosis (MS) at the European Academy of Neurology (EAN) annual meeting in Oslo, Norway. Norman Putzki, Global Program Head, Neuroscience at Novartis, said: "Mayzent is the only US Food and Drug Administration approved therapy for active SPMS based on evidence from a pivotal prospective Phase III clinical trial in a typical SPMS population. Mayzent can prevent cognitive decline, a fear of many MS patients, as cognitive decline can considerably affect the social and professional lives of these patients and their families. This high burden of MS inspires us to relentlessly reimagine ways to ease the impact of MS, including potential new treatments such as a novel self-injected B-cell therapy for relapsing forms of MS."

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About Novartis
Novartis is reimagining medicine to improve and extend people's lives. As a leading global medicines company, we use innovative science and digital technologies to create transformative treatments in areas of great medical need. In our quest to find new medicines, we consistently rank among the world's top companies investing in research and development. Novartis products reach more than 750 million people globally and we are finding innovative ways to expand access to our latest treatments. About 105 000 people of more than 140 nationalities work at Novartis around the world. Find out more at www.novartis.com.

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1.   Kuhle J, et al. Neurofilament Light Chain Levels in Blood are Predictive of Cognitive Impairment in Patients with Secondary Progressive Multiple Sclerosis. ePoster Session. 2019 European Academy of Neurology Annual Meeting, June 30, 2019.
2.   Benedict R, Fox R, Tomic D, et al. Siponimod Improves Cognitive Processing Speed in Patients with Secondary Progressive Multiple Sclerosis: EXPAND Subgroup Analyses. ePoster Session. 2019 European Academy of Neurology Annual Meeting, July 1, 2019.

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