Last Update: Jul 21, 2026
SEC-HOPE: A Multicenter Retrospective Cohort Study to Estimate Secukinumab Retention Rate in Psoriasis Patients With MASLD
ClinicalTrials.gov Identifier:
Novartis Reference Number:CAIN457AES18
All compounds are either investigational or being studied for (a) new use(s). Efficacy and safety have not been established. There is no guarantee that they will become commercially available for the use(s) under investigation.

Study Description

This study aims to examine the retention rate of secukinumab in adult patients with plaque psoriasis (with or without psoriatic arthritis \[PsA\]) and metabolic dysfunction-associated steatotic liver disease (MASLD) in routine clinical practice in Spain, as well as hepatic biomarker trajectories. The study will use electronic medical record (EMR) data from multiple Spanish hospitals.

Plaque Psoriasis, Metabolic Dysfunction-Associated Steatotic Liver Disease
Recruiting
150
Jul 08, 2026
Jan 15, 2027
All
18 Years - 100 Years (Adult, Older Adult)

Eligibility Criteria

Inclusion criteria:

* Patients with a first recorded secukinumab prescription between 01 January 2021 and 31 December 2023.
* Patients aged ≥18 years at index date.
* Patients with no prior secukinumab exposure in available EMR history.
* Secukinumab must be patient's first-, second-, or third-line biologic therapy for psoriasis/psoriatic arthritis (PsA).
* Patients with documented administration per Summary of Product Characteristics dosing recommendations (SmPC).
* Patients with confirmed plaque psoriasis with or without PsA.
* Patients with at least one cardiometabolic risk factor.
* Patients with a confirmed MASLD diagnosis.
* Patients with baseline laboratory data available.

Exclusion criteria:

* Patients with evidence of MASLD absence.
* Patients with malignant liver disease.
* Patients with a history of liver transplantation.
* Patients with alcohol use disorder.
* Patients with other chronic liver diseases.
* Patients with diseases or treatments which cause thrombocytopenia.
* Patients with decompensated cirrhosis.

Other protocol-defined inclusion/exclusion criteria may apply.

Novartis Investigative Site

Recruiting

Badalona,Barcelona,08916,Spain

Novartis Investigative Site

Recruiting

Madrid,28041,Spain

Novartis Investigative Site

Recruiting

Málaga,29010,Spain

Worldwide Contacts

If the location of your choosing does not feature any contact detail, please reach out using the information below.

Novartis Pharmaceuticals