Study Description
This is a prospective, multicenter, observational, non-interventional study (NIS) in patients with Multiple Sclerosis (MS) and routinely assessed serum neurofilament light (sNfL) values in Germany Prospective, primary data will be collected from patients with sNfL outcomes in the context of switching to ofatumumab or continuing their current therapy. Data collection will cover a maximum period of 24 months.
The observational period will not be dictated by the protocol. Baseline and follow-up visits will take place at a frequency defined as per Investigator´s discretion following clinical routine. The diagnostic or monitoring procedures are only those ordinarily applied to therapeutic strategy and routine clinical care. During the observation phase of the study, data will be collected according to standard of care as recommended by KKNMS (Competence Network Multiple Sclerosis in Germany).
Eligible participants for the study are patients who have received treatment with category 1 DMTs and those who have included sNfL into their treatment decision-making process. These patients have the option to either continue their current DMT or switch to ofatumumab. According to local treatment guidelines, DMT category 1 include dimethylfumarate/diroximelfumarate, glatirameroids, Interferon beta and teriflunomide. The decision to switch to ofatumumab or to continue the current DMT category 1 therapy must be made by the treating physician independently of the decision to enroll the patient in the study.
Interventions
DMT category 1
ofatumumab
Eligibility Criteria
Inclusion Criteria:
Participants eligible for inclusion in this study must meet all the following criteria:
1. Written informed consent must be obtained before participation in the study.
2. RMS patients aged 18 or older.
3. Treated in label with EU-approved DMTs for MS category 1 according to current guidelines (Hemmer et al 2023) for at least the last 3 months.
4. Presence of a sNfL test result from a commercially available test not older than 3 months.
Exclusion Criteria:
Participants meeting any of the following criteria are not eligible for inclusion in this study:
1. Patients being treated outside of the approved label of the respective DMT.
2. Simultaneous participation in any interventional study or simultaneous participation in another Novartis-sponsored non-interventional study with ofatumumab.
Novartis Investigative Site
Recruiting
Stuttgart,70174,Germany
Novartis Investigative Site
Recruiting
Bamberg,Bavaria,96052,Germany
Novartis Investigative Site
Recruiting
Bad Homburg,Hesse,61348,Germany
Novartis Investigative Site
Recruiting
Bad Krozingen,79189,Germany
Novartis Investigative Site
Recruiting
Bergneustadt,51702,Germany
Novartis Investigative Site
Recruiting
Berlin,10437,Germany
Novartis Investigative Site
Recruiting
Berlin,12163,Germany
Novartis Investigative Site
Recruiting
Bogen,94327,Germany
Novartis Investigative Site
Recruiting
Duisburg,47138,Germany
Novartis Investigative Site
Recruiting
Essen,45257,Germany
Novartis Investigative Site
Recruiting
Hamburg,22179,Germany
Novartis Investigative Site
Recruiting
Itzehoe,25524,Germany
Novartis Investigative Site
Recruiting
Regensburg,93059,Germany
Novartis Investigative Site
Recruiting
Remscheid,42853,Germany
Novartis Investigative Site
Recruiting
Siegen,57076,Germany
Novartis Investigative Site
Recruiting
Sundern Hachen,59846,Germany
Novartis Investigative Site
Recruiting
Tirschenreuth,95643,Germany
Novartis Investigative Site
Recruiting
Untermeiting,Bavaria,86836,Germany
Novartis Investigative Site
Recruiting
Düsseldorf,40211,Germany
Novartis Investigative Site
Recruiting
München,80939,Germany
Novartis Investigative Site
Recruiting
München,81675,Germany
Novartis Investigative Site
Recruiting
Albstadt,Baden-Wurttemberg,72458,Germany
Novartis Investigative Site
Recruiting
Hettingen,Baden-Wurttemberg,72513,Germany
Novartis Investigative Site
Recruiting
Mannheim,Baden-Wurttemberg,66163,Germany
Novartis Investigative Site
Recruiting
Schwetzingen,Baden-Wurttemberg,68723,Germany
Novartis Investigative Site
Recruiting
Neuburg an der Donau,Bavaria,86633,Germany
Novartis Investigative Site
Recruiting
Hamburg,Hamburg,22297,Germany
Novartis Investigative Site
Recruiting
Frankfurt am Main,Hesse,60311,Germany
Novartis Investigative Site
Recruiting
Frankfurt am Main,Hesse,65929,Germany
Novartis Investigative Site
Recruiting
Kassel,Hesse,34121,Germany
Novartis Investigative Site
Recruiting
Dortmund,North Rhine-Westphalia,44135,Germany
Novartis Investigative Site
Recruiting
Dortmund,North Rhine-Westphalia,44287,Germany
Novartis Investigative Site
Recruiting
Meerbusch,North Rhine-Westphalia,40667,Germany
Novartis Investigative Site
Recruiting
Siegen,North Rhine-Westphalia,57072,Germany
Novartis Investigative Site
Recruiting
Dresden,Saxony,01307,Germany
Novartis Investigative Site
Recruiting
Görlitz,Saxony,02828,Germany
Novartis Investigative Site
Recruiting
Leipzig,Saxony,04299,Germany
Novartis Investigative Site
Recruiting
Leipzig,Saxony,04315,Germany
Novartis Investigative Site
Recruiting
Altenburg,Thuringia,04600,Germany
Novartis Investigative Site
Recruiting
Jena,Thuringia,07740,Germany
Novartis Investigative Site
Recruiting
Mühlhausen,Thuringia,99974,Germany
Novartis Investigative Site
Recruiting
Aalen,73433,Germany
Novartis Investigative Site
Recruiting
Altenholz,24161,Germany
Novartis Investigative Site
Recruiting
Aschaffenburg,63739,Germany
Novartis Investigative Site
Recruiting
Augsburg,86150,Germany
Novartis Investigative Site
Recruiting
Backnang,71522,Germany
Novartis Investigative Site
Recruiting
Berlin,12099,Germany
Novartis Investigative Site
Recruiting
Berlin,12167,Germany
Novartis Investigative Site
Recruiting
Berlin,14057,Germany
Novartis Investigative Site
Recruiting
Berlin,14169,Germany
Novartis Investigative Site
Recruiting
Bielefeld,33647,Germany
Novartis Investigative Site
Recruiting
Bochum,44787,Germany
Novartis Investigative Site
Recruiting
Bonn,53111,Germany
Novartis Investigative Site
Recruiting
Chemnitz,09117,Germany
Novartis Investigative Site
Recruiting
Coburg,96450,Germany
Novartis Investigative Site
Recruiting
Dessau,06846,Germany
Novartis Investigative Site
Recruiting
Dillingen Saar,66763,Germany
Novartis Investigative Site
Recruiting
Dresden,01067,Germany
Novartis Investigative Site
Recruiting
Düsseldorf,40237,Germany
Novartis Investigative Site
Recruiting
Düsseldorf,40625,Germany
Novartis Investigative Site
Recruiting
Eisleben Lutherstadt,06295,Germany
Novartis Investigative Site
Recruiting
Eltville,65343,Germany
Novartis Investigative Site
Recruiting
Erbach im Odenwald,64711,Germany
Novartis Investigative Site
Recruiting
Erfurt,99096,Germany
Novartis Investigative Site
Recruiting
Essen,45138,Germany
Novartis Investigative Site
Recruiting
Gelsenkirchen,45879,Germany
Novartis Investigative Site
Recruiting
Gelsenkirchen,45894,Germany
Novartis Investigative Site
Recruiting
Gera,07548,Germany
Novartis Investigative Site
Recruiting
Göttingen,37073,Germany
Novartis Investigative Site
Recruiting
Hagen,58099,Germany
Novartis Investigative Site
Recruiting
Hanover,30159,Germany
Novartis Investigative Site
Recruiting
Heidenheim,89518,Germany
Novartis Investigative Site
Recruiting
Herford,32049,Germany
Novartis Investigative Site
Recruiting
Hoppegarten,15366,Germany
Novartis Investigative Site
Recruiting
Höxter,37671,Germany
Novartis Investigative Site
Recruiting
Karlsruhe,76133,Germany
Novartis Investigative Site
Recruiting
Katzenelnbogen,56368,Germany
Novartis Investigative Site
Recruiting
Leipzig,04109,Germany
Novartis Investigative Site
Recruiting
Lüneburg,21335,Germany
Novartis Investigative Site
Recruiting
Magdeburg,39120,Germany
Novartis Investigative Site
Recruiting
Merzig,66663,Germany
Novartis Investigative Site
Recruiting
Minden,32423,Germany
Novartis Investigative Site
Recruiting
Neuwied,56564,Germany
Novartis Investigative Site
Recruiting
Osnabrück,49074,Germany
Novartis Investigative Site
Recruiting
Pforzheim,75172,Germany
Novartis Investigative Site
Recruiting
Quakenbrück,49610,Germany
Novartis Investigative Site
Recruiting
Rülzheim,76761,Germany
Novartis Investigative Site
Recruiting
Salzatal,06198,Germany
Novartis Investigative Site
Recruiting
Schwalmstadt-Treysa,34613,Germany
Novartis Investigative Site
Recruiting
Schwäbisch Hall,74523,Germany
Novartis Investigative Site
Recruiting
Singen,78224,Germany
Novartis Investigative Site
Recruiting
Sinsheim,74889,Germany
Novartis Investigative Site
Recruiting
Stadtroda,07646,Germany
Novartis Investigative Site
Recruiting
Stuttgart,70178,Germany
Novartis Investigative Site
Recruiting
Ulm,89073,Germany
Novartis Investigative Site
Recruiting
Unterhaching,82008,Germany
Novartis Investigative Site
Recruiting
Velbert,42551,Germany
Novartis Investigative Site
Recruiting
Weiden,92637,Germany
Novartis Investigative Site
Recruiting
Weil der Stadt,71263,Germany
Novartis Investigative Site
Recruiting
Witten,58452,Germany
Novartis Investigative Site
Recruiting
Wolfenbüttel,38300,Germany
Worldwide Contacts
If the location of your choosing does not feature any contact detail, please reach out using the information below.