Research Disease Areas

We focus on discovering and advancing new treatments for serious patient needs. From the inception of a therapeutic through early clinical development, our disease area teams collaborate across scientific disciplines and organizations in support of our mission to improve and extend peoples’ lives.

Autoimmunity, Transplantation & Inflammatory Disease

B-cells in a kidney biopsy.

 

The Autoimmunity, Transplantation & Inflammatory Disease group is developing transformative therapies, including small molecules and biotherapeutics, that target the root cause of disease by modulating the immune system to restore health.

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Cardiovascular & Metabolic Diseases

Heart muscle cells.

 

Our Cardiovascular & Metabolic Diseases team works to better understand the root causes of cardiovascular and metabolic diseases, and discover and develop therapies against relevant targets.

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Exploratory Disease Research (DAx)

Liver cells

 

DAx catalyzes and drives transformative therapies for emerging, high-potential indications. Current research focuses on liver, respiratory and kidney diseases, as well as non-malignant blood disorders.

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Immuno-oncology

CAR-T cells in action.

 

Our Immuno-Oncology researchers are developing a deep and diverse portfolio of potential immune treatments for cancer.

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Musculoskeletal Diseases

Knee cartilage.

 

The mission of our Musculoskeletal Diseases research team is to restore mobility and independence to patients living with some of the most intractable of these conditions.

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Neuroscience

Astrocytes in a brain organoid.

 

Our neuroscience research team works to discover transformative therapies that address the underlying cause of neurodegenerative, neurodevelopmental and psychiatric diseases to dramatically improve the lives of patients.

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Oncology

Breast cancer cells.

 

Our Oncology team is developing a robust portfolio of treatments that destroy tumors selectively and strip away their defenses.

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Ophthalmology

Mouse retina

 

The Ophthalmology research team is working to develop a diverse portfolio of compounds – small molecules, biologics and gene-based treatments – that protect and restore vision.

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Tropical Diseases

Novartis Institute for tropical diseases

 

The Novartis Institute for Tropical Diseases is a drug discovery research institute dedicated to finding novel treatments for neglected tropical diseases, including malaria, cryptosporidiosis, and three major kinetoplastid diseases – human African trypanosomiasis, Chagas disease, and leishmaniasis.

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