Novartis Pipeline

Benefiting from our continued focus on innovation, Novartis has one of the industry’s most competitive pipelines. Many of these projects, which include new molecular entities as well as additional indications and different formulations for marketed products, are for medicines that could significantly advance treatment standards for patients worldwide. This table provides an overview of selected projects in development. Please note: the Novartis Pipeline data is updated quarterly.

Download the Novartis pipeline as of December 31, 2022 (PDF 0.1 MB)

Show Filters
Showing 136 results
  • MBL949
    Obesity related diseases
    Cardiovascular Phase 2
    Lead Indication
  • MGY825
    Solid Tumors Phase 1 KARS (Lysyl-tRNA synthetase) Inhibitor
    Lead Indication
  • MHU650
    Diabetic eye diseases
    Ophthalmology Phase 1
    Lead Indication
  • MHV370
    Systemic lupus erythematosus (SLE)
    Immunology Phase 1
    New Indication
  • MHV370
    Mixed connective tissue disease
    Immunology Phase 2
  • MHV370
    Sjorgen’s Syndrome (SjS)
    Immunology Phase 2
    Lead Indication
  • MIJ821
    Major depressive disorder with acute suicidal ideation or behavior
    Neuroscience Phase 2 >=2026 NR2B negative allosteric modulator
    Lead Indication
  • MIK665
    Hematological malignancies
    Hematology Phase 1 MCL1 inhibitor
    Lead Indication
  • NGI226
    Immunology Phase 1
    Lead Indication
  • NIO752
    Progressive supranuclear palsy
    Neuroscience Phase 1 Tau antagonist
    Lead Indication
  • NIO752
    Alzheimer’s disease
    Neuroscience Phase 1 Tau antagonist
    Lead Indication
  • NIR178
    NIR178, spartalizumab
    Solid Tumors Phase 1 Ad2AR Inhibitor, PD1 Inhibitor (Anti-PD-1 monoclonal antibody)
    Lead Indication
  • NIS793
    1L Metastatic pancreatic ductal adenocarcinoma
    Solid Tumors Phase 3 2025 TGFB1 inhibitor
    Lead Indication
  • NIS793
    NIS793, spartalizumab
    1L metastatic colorectal cancer
    Solid Tumors Phase 2 TGFB1 inhibitor
  • NZV930
    NZV930, spartalizumab, NIR178
    Solid tumors
    Solid Tumors Phase 1 CD73 Antagonist
    Lead Indication
  • OAV101
    Spinal muscular atrophy (SMA) IT administration
    Neuroscience Phase 3 2025 Survival motor neuron (SMN1) gene replacement therapy
    Supplementary Indication
  • OMB157
    Multiple sclerosis, pediatrics
    Neuroscience Phase 3 >=2026 CD20 Antagonist
    Supplementary Indication
  • PHE885
    4L multiple myeloma
    Hematology Phase 2 BCMA cell therapy
    Lead Indication
  • PIT565
    B-cell malignancies
    Hematology Phase 1
    Lead Indication
  • PKC412
    Acute myeloid leukemia, pediatrics
    Hematology Phase 2 >=2026 Multi-targeted kinase inhibitor
    Supplementary Indication

Combination abbreviations:
fulv    fulvestrant
tmx    tamoxifen
gsn    goserelin
NSAI  Non-steroidal aromatase inhibitor
Taf     Tafinlar® (dabrafenib)
Mek   Mekinist® (trametinib)

a    EU filing, approved in US.
b    US filing, approved in EU.
c    US filing, submitted in EU.
d    US pending submission, approved in EU
e    EU filing, submitted in US.


This information was factually accurate on the date it was published. Novartis assumes no duty to update the information to reflect subsequent developments. Readers should not rely upon the information on this page as current or accurate after its publication date. For the latest information on the Novartis' pipeline, readers should visit the News and Investors sections of our website. This information constitutes forward-looking statements relating to Novartis AG's business, including express or implied discussions regarding potential new products, potential new indications for existing products, or regarding potential future revenues from any such products. Such forward-looking statements reflect the current views of Novartis AG regarding future events, and involve known and unknown risks, uncertainties and other factors that may cause actual results to be materially different from any future results, performance or achievements expressed or implied by such statements. There can be no guarantee that any new products will be approved for sale in any market, or that any new indications will be approved for existing products in any market, or that such products will achieve any particular revenue levels.

In particular, management's expectations could be affected by, among other things, uncertainties involved in the development of new pharmaceutical products; unexpected clinical trial results, including additional analysis of existing clinical data or unexpected new clinical data; unexpected regulatory actions or delays or government regulation generally; the Novartis Group's ability to obtain or maintain patent or other proprietary intellectual property protection, including the uncertainties involved in the US litigation process; competition in general; government, industry, and general public pricing and other political pressures; and other risks and factors referred to in Novartis AG's current Form 20-F on file with the US Securities and Exchange Commission. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those described herein as anticipated, believed, estimated or expected.