Mar 22, 2024

About the Role

The position is located in Cambridge, MA and will not have the ability to be located remotely.


About the role:

We are seeking an experienced translational modeler eager to accelerate drug discovery & development by facilitating rigorous decision making with modeling & simulation, from target identification to first-in-human studies and beyond. You will work in a multi-disciplinary environment with opportunities to engage in projects that span different therapeutic modalities.

This role reports to a PK Sciences Translational Modeling team lead within Translational Medicine in Biomedical Research.

Key responsibilities:

• Act as the Translational M&S representative on programs in oncology, developing and executing modeling strategies, contributing to project team discussions, and guiding therapeutic design and dose selection decisions.

• Build and apply QSP and physiologically based PK (PBPK) models that link drug pharmacology, tissue biodistribution, mechanism(s) of action, and biological outcomes.

• Advance the development of integrated modeling platforms that bridge data and knowledge across preclinical species and patients, partnering with discovery project teams as well as the preclinical safety and pharmacometrics groups.

• Contribute to programs across therapeutic modalities and disease indications, as needed. Novartis has a wide portfolio with hundreds of drug discovery and clinical development projects and you will have opportunities to grow and develop as you apply modeling insights to diverse projects.

• Proactively seek opportunities to increase the impact and awareness of translational modeling through communications with internal and external audiences.


Diversity & Inclusion / EEO

We are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Accessibility and Reasonable Accommodations: Individuals in need of a reasonable accommodation due to a medical condition or disability for any part of the application process, or to perform the essential functions of a position, please let us know the nature of your request, your contact information and the job requisition number in your message:

Role Requirements

Essential requirements:

Ph.D. in biology, pharmaceutical sciences, bioengineering, biophysics, or a related field, or a master’s degree with 4+ years of industry experience. Candidates with a Pharm.D. or background in mathematics or other quantitative fields and a deep understanding of biological concepts will be considered.

Prior experience in quantitative systems pharmacology (QSP), pharmacokinetics and pharmacodynamics (PKPD), and/or physiologically based PK (PBPK) modeling is strongly preferred.

Expert level proficiency in core modeling fundamentals is required, including scripting languages (e.g., MATLAB, R), construction of ordinary differential equation (ODE) models, parameter estimation, and data visualization.

Demonstrated ability to communicate modeling results to a multidisciplinary audience to facilitate strategy and decision-making.

Fluent in English (oral and written).

#ModelingAndSimulation #PKSciences #TranslationalMedicineQuants

Why Novartis: Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture

You’ll receive:
You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook.

Commitment to Diversity & Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams’ representative of the patients and communities we serve.

Accessibility and Reasonable Accommodations: The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to [email protected] call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Novartis Compensation and Benefit Summary: The pay range for this position at commencement of employment is expected to be between $130,400 - $195,600/year; however, while salary ranges are effective from 1/1/24 through 12/31/24, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills, and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to learn more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network

Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture

Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network

Biomedical Research
Translational Medicine
Cambridge, MA
Research & Development
Full Time
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Principal Scientist, Translational Modeling & Simulation

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