Active Clinical Trials

Clinical trials are at the heart of our work to bring innovative medicines to people with a particular disease or condition. Learn more about the active studies conducted by Novartis including opportunities to get involved.

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Study title Condition Phase Location

Study of Efficacy and Safety of JDQ443 Single-agent as First-line Treatment for Patients With Locally Advanced or Metastatic KRAS G12C- Mutated Non-small Cell Lung Cancer With a PD-L1 Expression < 1% or a PD-L1 Expression ≥ 1% and an STK11 Co-mutation.

Locally Advanced or Metastatic KRAS G12C-mutated NSCLC With a PD-L1 Expression <1% or a PD-L1 Expression ≥ 1% and an STK11 Co-mutation Phase 2 United States
Turkey
Malaysia
Greece
Thailand
Spain
Italy
China
Brazil
Germany
Bulgaria
Netherlands
France
Argentina
Austria
India
Portugal
Hungary
Belgium
Singapore
United Kingdom
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Study of MGY825 in Patients With Advanced Non-small Cell Lung Cancer

Non-small Cell Lung Cancer Phase 1 United States
Spain
Japan
Germany
Switzerland
Korea, Republic of
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Study of JDQ443 in Comparison With Docetaxel in Participants With Locally Advanced or Metastatic KRAS G12C Mutant Non-small Cell Lung Cancer

Non-Small Cell Lung Cancer Phase 3 United States
Turkey
Romania
Spain
Jordan
Lebanon
Greece
Australia
Italy
India
Thailand
China
Serbia
Hungary
Argentina
Korea, Republic of
Mexico
Norway
Slovenia
Vietnam
Hong Kong
Brazil
Malaysia
Canada
Portugal
Colombia
Denmark
Czech Republic
Bulgaria
Iceland
Poland
Chile
United Kingdom
Taiwan
Estonia
Finland
Croatia
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Survey Among Healthcare Professionals Treating Patients With Metastatic Breast Cancer in Selected European Countries to Evaluate Their Knowledge on Management of Hyperglycemia When Using Alpelisib

Breast Cancer Switzerland

Study to Assess the Efficacy and Safety of Alpelisib Plus Fulvestrant in Participants With HR-postitive (HR+), HER2-negative, Advanced Breast Cancer After Treatment With a CDK4/6 Inhibitor and an Aromatase Inhibitor.

Breast Cancer Phase 3 Spain
Denmark
Greece
Germany
Italy
France
Slovakia
Czech Republic
Belgium
Hungary
Poland
Canada
Portugal
Romania
Ireland
Finland
Bulgaria
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A NIS of Alpelisib in Combination With Fulvestrant in Postmenopausal Women, and Men, With HR+,HER2- , Locally Advanced or Metastatic Breast Cancer With a PIK3CA Mutation, After Disease Progression Following Endocrine Therapy as Monotherapy, in the Real-world Setting

Hormone Receptor Positive HER2 Negative Breast Cancer With a PIK3CA Mutation Spain
Italy

Study of Efficacy and Safety of Dabrafenib Plus Trametinib in Previously Treated Patients With Locally Advanced or Metastatic, Radio-active Iodine Refractory BRAFV600E Mutation-positive Differentiated Thyroid Cancer

Differentiated Thyroid Cancer Phase 3 United States
Turkey
China
Brazil
Argentina
India
Mexico
Canada
Vietnam
Malaysia
Korea, Republic of
Taiwan
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