Summary
The TM Discovery & Profiling (TMDP) is a group of physicians and clinical researchers who drive innovative science from discovery to the patient through the selection, profiling, and effective development of medicines. Translational medicine experts oversee Phase 1 and 2 clinical trials to demonstrate proof-of-concept (PoC) in patients, as well as support for Phase 3 development. Translational medicine experts are key and highly visible members of global cross-functional project teams that design and implement early research and
discovery projects, that then culminate in clinical PoC studies. Translational medicine experts collaborate with colleagues in biology and chemistry to identify targets in diseases with significant unmet medical needs and provide input on likely clinical development pathways. The PoC studies led by our translational medicine experts are among the most critical steps in drug development at Novartis. After PoC and if the program proceeds to full development, the translational medicine expert continues as a key member of the full development team up to and including registration.
About the Role
Job title (Cardiologist Scientist Associate Director, Level 5 / Cardiologist Scientist Director, Level 6 and associated responsibilities will be commensurate with the successful candidates’ level of expertise)
This position will be located in Basel, Switzerland
#LI-Hybrid
About the role:
As a Cardiovascular Metabolism (CVM) TM Expert, you will collaborate with the CVM TM Head or other experienced TM Expert to develop high value decision-strategies for the Translational Medicine component of drug development projects and lead global cross-functional project teams through the PoC phase and beyond.
Job Description
Key Responsibilities:
- Lead global project teams through PoC phase to drive implementation of the PoC strategy; participate in project teams through program life cycle from NTRC to registration
- Responsible for clinical portions of the Integrated Development Plan (IDP) through PoC.
- Acts as medical monitor for one or more clinical studies
- Communicate clinical team matters to project teams and relevant decision boards (Disease Area Decision Board).
- Convene relevant (internal and external) leaders to consider proposed approach to PoC.
- Evaluate clinical centers and foster communication with crucial collaborating investigators
- Oversee publication and external presentation of PoC clinical study results
- Accountable for compound related biomarker strategies; work closely with biomarker experts in implementation
- In collaboration with research scientists identify, develop and implement strategy for preclinical support of program related objectives; this includes assessment of medical need, proposal of clinical development pathways, and review of preclinical data for clinical implications and other relevant activities
- Participate in team presentations to Health Authorities as TM Expert
Essential Requirements:
- Doctoral degree, MD required with clinical subspecialty training preferred in cardiovascular disease or endocrinology/metabolic disease; Additional PhD/post-doctoral equivalent research preferred.
- At least 1-2 years’ experience in a pharmaceutical/biotech company, CRO, or academic medical center, or related experience; 5 plus years to be considered for Director level.
- Recognized for medical expertise.
- Recognized for scientific expertise: respected by colleagues internally and externally, have made significant contributions to the field and created / established new concepts; record of high quality publications in international scientific journals.
- Excellent written and oral communication/presentation skills.
- Independence: Able to work independently on study planning and execution, and with supervision on project planning.
- Leadership of Collaborations: Able to lead multidisciplinary teams in a matrix organization.
- Innovation: Seeks out new clinical discovery opportunities and PoC approaches.
- Additional consideration for candidates with advanced research experience in data science, genetics/genomics, AI or digital methods in electrocardiography and/or cardiovascular imaging.
- Demonstrated passion for science.
Commitment to Diversity and Inclusion / EEO paragraph
Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.
Accessibility and Accommodation:
Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to inclusion.switzerland@novartis.com and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture
Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network
Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards
Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture
Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards
Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.
