Effectiveness of Brolucizumab in Pre-treated Patients With nAMD in the Real-world Setting

Inclusion Criteria:

Diagnosis of nAMD
Patients with ≥18 years of age at index
Receipt of at least one injection of brolucizumab (not necessarily the first one) during the index period
Signed informed consent

Exclusion Criteria:

Patients treated for retinal vein occlusion (RVO), diabetic macular edema (DME), myopic choroidal neovascularization (mCNV), and have diagnoses of diabetes-related macular degeneration within 6 months prior to the index date
Receipt of any anti-VEGF treatment other than brolucizumab in the study eye during the index period
Receipt of brolucizumab in the study eye more than 6 months before the index period, i.e., brolucizumab treatment started more than 6 months before the start of the study
Any active intraocular or periocular infection or active intraocular inflammation in the study eye at index date
Patients who have any contraindication and are not eligible for treatment with brolucizumab as according to the label
Patients who were treated with more than 2 types of anti-VEGF before index date (4th line brolucizumab patients or more)
Any medical or psychological condition in the treating physician's opinion which may prevent the patient from the 12-month study participation
Patients participating in parallel in an interventional clinical trial Note: if a patient experiences an adverse event (AE), they may still be recruited in another study following this AE if they fulfill their inclusion criteria. Their data will still be collected as planned by the current protocol
Patients participating in parallel in any other NIS generating primary data for an anti-VEGF drug