Global Discovery Chemistry
The Natural Products and Biomolecular Chemistry group (NPBC) enables and drives activities of drug discovery and development with compounds derived from natural sources, and biomolecules such as enzymes and peptides. This encompasses the identification of new, biologically active natural products from microorganisms to optimization of the producer strains by genetics and physiological strategies in combination with process development in the mid-scale fermentation and isolation plant.
Eukaryotic systems (filamentous fungi, yeasts and plants) are the focus of our team. We engage a multidisciplinary approach involving genome mining, target identification, and genetic engineering of biosynthetic pathways to discover and produce new pharmaceutically-relevant molecules.