394253BR
Mar 18, 2024
Switzerland
About the Role
There is a unique opportunity for a Discovery Postdoctoral Fellow to explore the underlying biology of novel Radioligand Therapies (RLTs), including the effect of RLTs on the tumor and its stromal microenvironment.
The Discovery Fellow will have the opportunity to conduct innovative, interdisciplinary research and publish their results in leading journals. You will be part of our Oncology, Pharmacology team in Basel, Switzerland working very closely with Oncology Data Sciences.
RLT is a form of precision nuclear medicine which specifically directs radiation to target cells in the tumor. This cutting-edge technology has demonstrated remarkable promise for cancer patients, with two Novartis compounds- Pluvicto (177Lu-PSMA-617) and Lutathera (177Lu-DOTATATE) recently gaining approval in patients with mCRPC and GEP-NETs respectively. As a new and emerging modality there is still a lot to learn about how RLTs engage with the tumor and modulate its stromal microenvironment.
Preferred start date: as soon as possible (negotiable)
Duration: 36 to 48 months
Location: Novartis Campus, Basel, Switzerland
Key responsibilities
As a Discovery Fellow, you will:
• Actively design and shape the research project.
• Design and implement in vivo studies with syngeneic tumor models. Carry out ex vivo analysis of tumors by flow cytometry using large lymphoid/myeloid panels, single cell RNA Seq, IHC/IF etc.
• Implement reductionist in vitro assays of CAF and immune cell function.
• Work closely with data sciences to inform research questions and experiments.
• Collaborate with Novartis researchers and academic partners.
• Present at lab meetings, internal seminars and international conferences.
• Publish research findings in leading peer-reviewed journals.
#LI-Onsite
#PDX
The Discovery Fellow will have the opportunity to conduct innovative, interdisciplinary research and publish their results in leading journals. You will be part of our Oncology, Pharmacology team in Basel, Switzerland working very closely with Oncology Data Sciences.
RLT is a form of precision nuclear medicine which specifically directs radiation to target cells in the tumor. This cutting-edge technology has demonstrated remarkable promise for cancer patients, with two Novartis compounds- Pluvicto (177Lu-PSMA-617) and Lutathera (177Lu-DOTATATE) recently gaining approval in patients with mCRPC and GEP-NETs respectively. As a new and emerging modality there is still a lot to learn about how RLTs engage with the tumor and modulate its stromal microenvironment.
Preferred start date: as soon as possible (negotiable)
Duration: 36 to 48 months
Location: Novartis Campus, Basel, Switzerland
Key responsibilities
As a Discovery Fellow, you will:
• Actively design and shape the research project.
• Design and implement in vivo studies with syngeneic tumor models. Carry out ex vivo analysis of tumors by flow cytometry using large lymphoid/myeloid panels, single cell RNA Seq, IHC/IF etc.
• Implement reductionist in vitro assays of CAF and immune cell function.
• Work closely with data sciences to inform research questions and experiments.
• Collaborate with Novartis researchers and academic partners.
• Present at lab meetings, internal seminars and international conferences.
• Publish research findings in leading peer-reviewed journals.
#LI-Onsite
#PDX
Diversity & Inclusion / EEO
We are committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.
Role Requirements
Role Requirements:
• PhD in Oncology, Molecular and Cellular Biology or related subject area (PhD students in the last year of their thesis work, are eligible to apply).
• Hands on experience with in vivo tumor models and ex vivo analysis by flow cytometry.
• Substantial experience with standard in vitro cell biology techniques (cell culture, lenti/retroviral infection, western blot, IF, qPCR etc).
• Experience working with radioisotopes is highly desirable though not essential.
• Strong publication record or other scientific achievements (i.e. awards, patents, grants)
• Excellent analytical, communication, presentation and organizational skills
• Passion for fundamental exploratory research and boundless curiosity
How to apply
Please submit your CV and cover letter by April 15 for consideration. Please make sure to discuss in the cover letter how this training program will help you fulfill your career goals.
Why Novartis:
Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture
Accessibility and accommodation
Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable
accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to
[email protected] and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network
• PhD in Oncology, Molecular and Cellular Biology or related subject area (PhD students in the last year of their thesis work, are eligible to apply).
• Hands on experience with in vivo tumor models and ex vivo analysis by flow cytometry.
• Substantial experience with standard in vitro cell biology techniques (cell culture, lenti/retroviral infection, western blot, IF, qPCR etc).
• Experience working with radioisotopes is highly desirable though not essential.
• Strong publication record or other scientific achievements (i.e. awards, patents, grants)
• Excellent analytical, communication, presentation and organizational skills
• Passion for fundamental exploratory research and boundless curiosity
How to apply
Please submit your CV and cover letter by April 15 for consideration. Please make sure to discuss in the cover letter how this training program will help you fulfill your career goals.
Why Novartis:
Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture
Accessibility and accommodation
Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable
accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to
[email protected] and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network
Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture
Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network
Biomedical Research
Oncology NIBR
Switzerland
Basel
Novartis Pharma AG
Interns/Students on Novartis Payroll
Full Time
Internship
No
