Meeting the challenges of treating neurodegenerative, psychiatric and neurodevelopmental diseases with science and technology.

Imagine being able to recreate a piece of your brain in a lab to understand how your brain really works. Our neuroscience researchers are harnessing revolutionary new technologies - including the ability to grow mini-brain organoids in the lab - to build human models of neurological disease.

Astrocytes in a brain organoid.
A super-resolution microscopy image of astrocytes in a brain organoid. Credit Max Salick

Psychiatric and neurodegenerative diseases place a heavy physical, emotional and economic burden on patients and their families. We believe that we can make new treatments that will modify the course of disease and dramatically improve patient lives.

Neuroscience research at Novartis is focused on three primary areas of research:

  • In children, we are focusing on spinal muscular atrophy (SMA), Rhett syndrome, autism spectrum disorders, intellectual disabilities and epileptic encephalopathies.
  • In adult psychiatry, we are focusing on bipolar disorder, depression, substance use disorders and schizophrenia.
  • In neurodegeneration, we are working on Alzheimer’s disease, Parkinson’s disease, frontotemporal dementia and several rare monogenic diseases. We are also working to improve the treatment of multiple sclerosis.

To guide drug discovery and research efforts, we use technologies that enable us to develop models of disease that are more predictive by making them more human. For instance, we take skin or blood cells from patients and, using our induced pluripotent stem cell platform, convert them into neurons and then into miniature brain-like organoids. In parallel, we also have the capacity to manipulate neural circuits using optogenetics - the use of light to control the activity of single neurons.

We are also developing gene therapies to address genetic conditions, especially diseases caused by the mutation of a single gene. Gene therapy works by replacing a missing or defective gene with a working copy that makes a functional protein, thereby halting disease progression.

To succeed, we need to be daring and we need the best people to work on these problems. It won’t be easy or fast, but we believe it’s possible and we are committed to helping patients in need.

Reimagine medicine with Novartis

Learn about opportunities to join our team