Antibodies are essential to the humoral immune response against pathogens and constitute one of the first lines of defense against re-infection, and they can persist over time even in the absence of antigens. The cellular basis of serological memory is represented by: 1) memory B cells and 2) plasma cells. While we have in-depth knowledge on the role of humoral responses against pathogens, the contribution of memory B cells and plasma cells to auto-reactive responses is not completely understood.
Our research is focused in understanding the innate mechanisms that contribute in the regulation of the human B cells, and how these mechanisms are implicated in both protective as well as autoimmune responses.
Three main research activities will be developed in the lab:
Understanding the innate mechanisms that control human B cell responses
Dissecting the role of B cells in autoimmunity and immundeficiencies by studying human monogenic autoimmune diseases
Developing a B cell selection platform with high-throughput culture methods and molecular sequencing approaches, such as single cell PCR and next-generation sequencing of antibodies from different species (i.e., rabbit, llama)
Loss of immune tolerance to IL-2 in type 1 diabetes. Pérol L, Lindner JM, Caudana P, Nunez NG, Baeyens A, Valle A, Sedlik C, Loirat D, Boyer O, Créange A, Cohen JL, Rogner UC, Yamanouchi J, Marchant M, Leber XC, Scharenberg M, Gagnerault MC, Mallone R, Battaglia M, Santamaria P, Hartemann A, Traggiai E, Piaggio E. Nat Commun. 2016 Oct 6;7:13027.