Across our genome, DNA elements with non-coding, yet key regulatory function, harbor characteristic epigenetic signatures that ultimately impact transcriptional output. Such elements are bound and controlled by a tightly regulated and highly interconnected network of transcription factors and co-factors to shape the gene expression landscape determining cell identity and pathological states.
Our laboratory is interested in functionally dissecting such Transcriptional Networks in cancer subtypes bearing specific genetic lesions. To this end, we extensively perform functional genomics studies to interrogate the dependency of cancer models on oncogenic transcription factors (TF), their pathway modulators and target genes in order to identify novel cancer vulnerabilities. Moreover, we perform epi-/genomic and proteomic profiling on novel TFs to further characterize the molecular mechanisms underlying their oncogenic role.