Aron Jaffe is the Cambridge Regenerative Medicine Hub Leader for the Developmental and Molecular Pathways department. The group’s mission is to identify and validate novel targets and therapies that promote tissue protection, repair, and regeneration. A major area of focus for the group is establishing and utilizing complex (three-dimensional) cellular and organotypic models that mimic in vivo properties epithelial tissues, to drive the identification of key druggable nodes in fundamental cellular processes that are de-regulated in disease. Prior to joining Novartis in 2008, Aron performed his post-doctoral training at the MRC Laboratory for Molecular Cell Biology in London, UK, and the Memorial Sloan-Kettering Cancer Center in New York, where he established a three-dimensional culture model of intestinal epithelial morphogenesis to study the cellular functions of the Rho family of small GTPases. Aron received his B.S. in Biochemistry from the University of Illinois at Urbana-Champaign, and his PhD from the University of Pennsylvania School of Medicine in Cell and Molecular Biology.