Chemical Biology & Therapeutics
Cambridge, Massachusetts, United States
My lab has been working on adapting, optimizing and developing robust gene editing tools for drug discovery programs at Novartis. We have successfully implemented zinc finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN) and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR associated protein 9 (Cas9) mediated gene targeting methodologies in multiple model systems including zebrafish, mice, human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells. Our goal is to establish a high throughput genome engineering platform and apply it for discovery of novel therapeutic strategies.