Disease Area X
Our research focuses on the blood and lymphatic vascular systems and their role in kidney disease. Chronic kidney disease is a major public health issue, with increasing incidence worldwide. The highly complex kidney vascular network is critical for maintaining glomerular and tubular functions, yet we are only starting to understand how heterogeneous kidney endothelial cells are and how they contribute to kidney homeostasis and pathophysiology.
We use complex assays with primary human cells, organoids and animal models, and apply state of the art profiling technologies to investigate different endothelial cell functions such as formation of the endothelial barrier, sprouting lymph/angiogenesis and flow shear stress sensing. It is our goal to discover novel factors that affect kidney vascularization and vessel functionality and to expand our knowledge on the molecular pathways involved. By increasing the functionality of the kidney microvasculature, we aim to generate novel therapeutic opportunities.
CNS distribution, signalling properties and central effects of G-protein coupled receptor 4.
Hosford PS, Mosienko V, Kishi K, Jurisic G, Seuwen K, Kinzel B, Ludwig MG, Wells JA, Christie IN, Koolen L, Abdala AP, Liu BH, Gourine AV, Teschemacher AG, Kasparov S.
Neuropharmacology. 2018 Aug;138:381-392.
Blockade of VEGF receptor-3 aggravates inflammatory bowel disease and lymphatic vessel enlargement.
Jurisic G, Sundberg JP, Detmar M.
Inflamm Bowel Dis. 2013 Aug;19(9):1983-9.
An unexpected role of semaphorin3a-neuropilin-1 signaling in lymphatic vessel maturation and valve formation.
Jurisic G, Maby-El Hajjami H, Karaman S, Ochsenbein AM, Alitalo A, Siddiqui SS, Ochoa Pereira C, Petrova TV, Detmar M.
Circ Res. 2012 Aug 3;111(4):426-36.
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