Autoimmunity, Transplantation and Inflammation
T and B lymphocytes are critical players in multiple autoimmune disorders. My research activities have focused on investigating the relevance of various signaling nodes and pathways downstream of major immunoreceptors (e.g., TCR, BCR, activating and inhibitory receptors, etc.) in both T cells and B cells and to use this information to design new therapeutic approaches aimed at inhibiting pathogenic immune responses.
Our laboratory relies on the use of a wide array of cellular in vitro techniques, functional assays (human, rat or mouse cells), animal models and multicolor flow cytometry analyses to assess the effect of drug candidates (biologics and low molecular weight compounds) on various adaptive and innate immune cell subsets. Our research also involves the generation and detailed characterization of genetically modified animals to investigate the in vivo biological relevance of novel drug targets. Given the importance of immune cells in anti-tumor immunity, we are also using our knowledge to develop innovative drugs aiming at boosting immune responses to cancer.
Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies.
Pellegrini M*, Calzascia T*, Elford AR, Shahinian A, Lin AE, Dissanayake D, Dhanji D, Nguyen LT, Gronski MA, Morre M, Assouline B, Lahl K, Sparwasser T, Ohashi PS, Mak TW.
Nature Medicine 2009, 15:528-536.
*These authors contributed equally to this work
TNF-alpha is critical for antitumor but not antiviral T cell immunity in mice.
Calzascia T, Pellegrini M, Hall H, Sabbagh L, Ono N, Elford AR, Mak TW, Ohashi PS.
J.Clin.Invest 2007, 117:3833-3845.
Homing phenotypes of tumor-specific CD8 T cells are predetermined at the tumor site by crosspresenting APCs.
Calzascia T, Masson F, Di Berardino-Besson W, Contassot E, Wilmotte R, Aurrand-Lions M, Rüegg C, Dietrich PY, Walker PR.
Immunity 2005, 22:175-184.
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