393712BR
Apr 24, 2024
USA

Summary

About the role : Internal Job Title: Senior Scientist II Job Location: Cambridge, MA onsite About the Role: Disease Area X, a department within the Biomedical Research (BR) group of Novartis, focuses on diseases of critical human organs, including kidney, lung, and liver. We are seeking a scientist to join our interdisciplinary pharmacology team (Discovery and Translational Pharmacology) in support of our efforts to progress novel medicines toward the clinic, with an emphasis on renal diseases. In this role, you will work independently to design and implement in vivo and ex vivo studies for target identification, and for testing and validation of novel medicines. As a key member of drug discovery teams, your advice will be sought to determine next steps for experimentation in line with project needs. Your responsibilities include, but are not limited to: • Conducting experiments with animal models of kidney and other diseases of interest to DAx: administering candidate therapeutics to experimental animals, making clinical observations, and harvesting samples for the evaluation of drug levels, histology, and molecular endpoints. • Implementing ex-vivo bio-analysis on generated samples. Performing standard molecular biology or cell biology techniques (such as qPCR, ELISAs, Western blots, cell culture). • Working independently to design, execute and analyze in vivo studies in line with project needs and timelines. • Supporting the development of new in vivo models for chronic kidney diseases and other therapeutic areas. • Working collaboratively in a highly team-oriented and matrix environment to establish and maintain conscientious and adaptable working relationships with partners throughout BR. • Serving as a mentor for more junior members of the lab group and department; maintaining and using a network of connections in the company to incorporate new scientific techniques and team productivity. • Presenting your results in an engaging and thoughtful manner to teams within Disease Area X and across BR. • Working in compliance with the Novartis Code of Conduct and in accordance with Novartis guidelines on health and safety and data recording.

About the Role

About the Role:

Disease Area X, a department within the Biomedical Research (BR) group of Novartis, focuses on diseases of critical human organs, including kidney, lung, and liver. We are seeking a scientist to join our interdisciplinary pharmacology team (Discovery and Translational Pharmacology) in support of our efforts to progress novel medicines toward the clinic, with an emphasis on renal diseases. In this role, you will work independently to design and implement in vivo and ex vivo studies for target identification, and for testing and validation of novel medicines. As a key member of drug discovery teams, your advice will be sought to determine next steps for experimentation in line with project needs.

Essential Requirements:

• BS or MS degree (or equivalent) in Life Sciences, and a minimum of 6 years related laboratory experience in an academic or industrial drug discovery setting in an in vivo role.
• Proficiency with in vivo procedures in rodents including multiple dose routes of administration (PO, IV, SC, IP), blood/tissue collection and necropsies.
• Experience with biochemical assays (e.g. ELISA, qPCR, Western blotting etc.) and/or tissue culture/cell biology, plus experience in complex cellular models and/or ex vivo systems or explants.
• Highly proficient at multi-tasking and can easily adapt to new procedures and projects.
• Has curiosity and is able to identify complex problems and provide innovative solutions based on prior experience or on evaluation of the literature.
• Fluency and excellent communication skills in English.
• Strong organizational skills, self-motivation, attention to detail, flexibility, proactive willingness and desire to engage in the laboratory workflow.
• Team oriented and collaborative work ethic.
• Self-awareness and desire to develop your skills further.
• Proficiency in computer use and laboratory software programs.

Desirable Characteristics:

• Experience with rodent models of chronic kidney disease.

Why Novartis: Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture

You’ll receive: You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook: https://www.novartis.com/careers/benefits-rewards

Novartis Compensation and Benefit Summary: The pay range for this position at commencement of employment is expected to be between $102,400 to $153,600/year; however, while salary ranges are effective from 1/1/24 through 12/31/24, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills, and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.



Commitment to Diversity and Inclusion / EEO: The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network

Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture

Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network

Biomedical Research
Pharma Research
USA
Cambridge (USA)
Research & Development
Full time
Regular
No
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393712BR

Senior Scientist, Discovery and Translational Pharmacology

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