From the inception of a therapeutic through early clinical development, our disease area teams collaborate across scientific disciplines and organisations in support of our mission to improve and extend people's lives.

Acute Myeloid Leukemia (AML)

Acute myeloid leukemia (AML) is an aggressive cancer of the blood and bone marrow and is responsible for the largest number of leukemia deaths annually. 


Choroidal Neovascularisation (CNV)

Choroidal neovascularisation (CNV) describes what happens when abnormal blood vessels grow into a part of the eye called the retina.1


Chronic Myeloid Leukaemia (CML)

CML is a type of blood cancer that originates in the bone marrow. It develops slowly and typically affects those over the age of 60. CML causes the bone marrow to go into overdrive, producing too many white blood cells that are abnormal.

Diabetic Macular Oedema (DMO)

Diabetic macular oedema (DMO) is a complication of diabetes that affects an area at the back of the eye called the macula. It happens when blood vessels in the eye become damaged by poor control of blood sugar, causing swelling and bleeding that may lead to visual impairment. 2,3


Heart Failure

Heart failure (sometimes shortened to HF) is a condition where your heart is unable to pump blood around the body as well as it should. This can happen because the heart has become too weak or stiff. Heart failure is a long-term condition that tends to get slowly worse over time; however, the symptoms can often be controlled for many years.


Immune Thrombocytopenia

Immune thrombocytopenia(ITP) is an autoimmune disease that can cause excessive bruising or bleeding due to a reduced number of platelets in the blood. Learn more about immune thrombocytopenia.4,5



Inherited Retinal Dystrophies (IRDs)

IRD is used to describe a collection of rare eye conditions that are passed down from parents to children in the genes. IRDs are sometimes also called inherited retinal diseases or inherited retinal degenerations.6



Melanoma is a cancerous tumour that forms in the pigment-producing cells, known as melanocytes, which produce melanin that causes the skin to brown or tan. Learn more about melanoma.




Myelofibrosis (MF) is a rare type of blood cancer that typically develops slowly and tends to affect the over 50s. In MF, scar tissue develops in the bone marrow, where blood cells are produced. 7,8,9

Learn more

Myelodysplastic Syndrome

MDS represents a group of disorders that affects red blood cell (RBC) production in approximately 5 per 100,000 people. 15% of cases occur after chemotherapy or radiotherapy for a previous cancer, but the cause of most cases is unknown.10,11


Multiple Sclerosis (MS)

Multiple sclerosis (MS) is a long-term condition that affects the central nervous system (CNS), which is comprised of the brain and spinal cord. MS varies from person to person and not everyone’s MS is the same. Although MS is individual and everyone will have a different experience, broadly speaking there are three main types: relapsing-remitting MS, secondary progressive MS and primary progressive MS.


Neuroendocrine Tumours (NETs) and Acromegaly

There are many types of cells located throughout the body. One particular group of cells are known as neuroendocrine cells. These cells are unique because they can regulate both the nervous system and the endocrine (glands in the body that make and release hormones into the bloodstream) system.


Non-Small Cell Lung Cancer

Adenocarcinoma is the most common type of lung cancer, accounts for 40% of all lung cancer. It develops in the small airway epithelial, type II alveolar cells, which secrete mucus and other substances. Learn more about lung cancer. 12



Periodic Fever Syndromes

Periodic fever syndromes are a group of rare genetic diseases that cause the immune system to become overactive, leading to inflammation in the body. People with periodic fever syndromes experience repeated episodes of fever, rashes and joint pain (called “flares”) that can last from a few days to a few weeks. 13,14


Proliferative Diabetic Retinopathy (PDR)

Diabetic retinopathy is a complication of diabetes that occurs when poorly controlled blood sugar damages blood vessels in a part of the eye called the retina. Proliferative diabetic retinopathy (PDR) is one of the most severe types.15


Severe Asthma

Asthma is a common condition that affects the airways. It causes the airways to become inflamed and tightened, which leads to symptoms such as coughing, wheezing and breathlessness. 16,17


Sickle Cell Disease

SCD refers to a group of blood disorders caused by genetic faults that affect the production of healthy red blood cells (RBCs). This causes faulty RBCs to form a ‘crescent’ shape which can stick together and form blockages within blood vessels.18 Learn more about sickle cell disease.




Thalassaemia refers to a group of rare genetic blood disorders, estimated to affect 1 per 100,000 people worldwide. The two most common types of thalassaemia include alpha-thalassaemia and beta-thalassaemia that can exist in three different forms of severity (minor, intermediate and major). 19,20



Urticaria is another name for hives (or wheals). Hives are itchy, raised patches on the skin that can vary in shape, size and colour. They can appear anywhere on the body, are often extremely itchy, and can also cause a burning or stinging sensation.


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Reporting of side effects

If you get any side effects, talk to your doctor, pharmacist or nurse.  This includes any possible side effects not listed in the package leaflet. 

You can also report side effects directly via the Yellow Card Scheme at

By reporting side effects you can help provide more information on the safety of this medicine

  1. Dunaief J. What is choroidal neovascularization? Available at: [Accessed June 2020].
  2. Macular Society. Diabetic macular oedema. Available at: [Accessed June 2020].
  3. Moorfields Eye Hospital. Diabetic macular oedema. Available at: [Accessed June 2020].
  4. Guy’s and St Thomas’ NHS Foundation Trust. (2016). Immune Thrombocytopenia [Fact sheet]. Retrieved from: Last Accessed: 19th September 2019.
  5. Oxford University Hospitals NHS Trust. ITP Information for Patients (2015) [Fact sheet]. Retrieved from: Last Accessed: 02 October 2019.
  6. Retina international 2020 Accessed August 2020.
  7. Leukemia and Lymphoma Society. Myeloproliferative neoplasms. Myelofibrosis. Available at: Last accessed April 2020.
  8. Blood Cancer UK. What is myelofibrosis (MF)? Available at: Last accessed April 2020.
  9. Macmillan Cancer Support. Myelofibrosis. Available at: Last accessed April 2020.
  10. Mohammad AA. Myelodysplastic syndrome from theoretical review to clinical application view. OncolRev 2018;12(397):134–142.
  11. Adès L, et al. Myelodysplastic syndromes. Lancet 2014;383:2239–2252.
  12. Cancer Research UK. Lung cancer statistics available at:
  13. Periodic fever syndromes. Available at: [Accessed July 2020].
  14. Ciccarelli F et al. Curr Med Chem 2014;21(3):261–269.
  15. Moorfields Eye Hospital. Diabetic retinopathy. Available at: [Accessed June 2020].
  16. British Lung Foundation. What is asthma? Available at: [Accessed April 2020].
  17. Asthma UK. What is asthma? Available at: [Accessed April 2020].
  18. Quinn CT. Clinical severity in sickle cell disease: the challenges of definition and prognostication. Exp Biol Med (Maywood) 2016;241(7):679–688.
  19. Galanello R and Origa R. Beta-thalassemia. Orphanet J Rare Dis 2010;5:11.
  20. Taher AT and Saliba AN. Iron overload in thalassemia: different organs at different rates. Hematology Am Soc Hematol Educ Program. 2017;2017(1):265–271.