Resumen
Location: Menges, Slovenia
Role Purpose:
Our R&D unit in Mengeš is looking for a motivated scientist in field of Downstream Processing (DSP) to join us in Mengeš and help us develop a diverse portfolio of biotherapeutic modalities.
As a Senior Scientist you must demonstrate a broad and in-depth knowledge of technologies in recombinant protein production and purification to evaluate the developability of various biologics modalities covered by Novartis Biomedical Research and Development units, ranging from traditional antibodies to advanced biologics formats and mixed modalities, ensuring quality of material delivered and eventually enabling lead candidate selection.
We offer a stimulating work environment, ample opportunities for growth and development, and the chance to make a significant impact on the future of medicine. If you are a motivated and talented scientist with a passion for biomedical research, we invite you to apply and become a part of our dynamic team at Novartis.
Naša R&D enota v Mengšu išče motiviranega raziskovalca na področju izolacij bioloških učinkovin (DSP), ki se nam bo pridružil v Mengšu in nam pomagal razvijati raznolik portfelj bioterapevtikov.
Kot Raziskovalec ekspert morate izkazovati široko in poglobljeno poznavanje tehnologij za proizvodnjo in čiščenje rekombinantnih proteinov, da boste lahko ocenili razvojni potencial različnih bioloških terapevtskih kandidatov, ki jih pokrivajo enote Novartis Biomedicinske raziskave in Razvoj, od tradicionalnih protiteles do naprednih bioloških formatov in mešanih modalnosti, pri čemer boste zagotavljali kakovost dostavljenega materiala ter na koncu omogočili izbor vodilnega kandidata.
Ponujamo spodbudno delovno okolje, številne priložnosti za rast in razvoj ter možnost pomembnega vpliva na prihodnost medicine. Če ste motiviran in nadarjen znanstvenik s strastjo do biomedicinskih raziskav, vas vabimo, da se prijavite in postanete del naše dinamične ekipe v Novartisu.
About the Role
Key responsibilities
- Downstream purification of recombinantly expressed proteins from suspension CHO culture from small to large scale (up to 200L).
- Design, plan, perform and complete lab and preparative scale purifications of antibodies antibody derivatives and other novel protein formats using state-of-the-art equipment
- As DSP lead plan, manage and coordinate protein productions across multiple projects in cross-discipline project teams
- Independently generate hypotheses, design and execute follow-up experiments, and troubleshoot issues
- Lead technology projects for protein purification and conjugation in close collaboration with related line functions; incorporate latest technologies and knowledge into research activities and ongoing projects
- Author lab procedures and technology evaluations
- Accurately and timely process samples, contribute to result interpretation and prepare summary presentations and timely document all data in electronic lab journal and databases
- Actively undertake organizational responsibilities in lab organization and shipments, including maintaining equipment and implementation of new equpiment
Minimum Requirements - What you will bring to the role:
- MSc University degree in chemistry, biochemistry, chemical technology or other relevant discipline with at least 3 years of relevant work experience in industry, or BSc University degree in chemistry, biochemistry, chemical technology or other relevant discipline with at least 6 years of relevant work experience in industry
- Good theroretical and strong practical background in Downstream Processing of monoclonal and multispecific antibodies, including several years of hands-on experience with Aekta liquid chromatography, filtration, and centrifugation technologies
- Strong experience in experimental design and data analysis
- High learning ability to acquire expertise in new technologies and technical equipment
- Proven experience in successfully prioritizing and keeping timelines
- Open and proactive communication, ability to interact with various stakeholders
- Reliable and flexible team player, accustomed to sharing tasks and projects
- Fluency in English (oral/written)
Desirable skills:
- Solid experience in one of the neighboring disciplines (Upstream Processing and/or Phys-Chem protein analytics)
Ključne odgovornosti
- Izolacija rekombinantno izraženih proteinov iz suspenzijske CHO kulture od malega do velikega merila (do 200 L).
- Načrtovanje, planiranje, izvajanje in zaključevanje laboratorijskih ter preparativnih čiščenj protiteles, derivatov protiteles in drugih novih proteinskih formatov z uporabo najsodobnejše opreme
- Načrtovanje, upravljanje in koordinacija proizvodnje proteinov v več projektih znotraj interdisciplinarnih projektnih ekip kot funkcijski DSP vodja na projektu
- Samostojno oblikovanje hipotez, načrtovanje in izvedba nadaljnjih eksperimentov ter odpravljanje težav
- Vodenje tehnoloških projektov za čiščenje in konjugacijo proteinov v tesnem sodelovanju s sorodnimi linijskimi funkcijami; vključevanje najnovejših tehnologij in znanja v raziskovalne aktivnosti in tekoče projekte
- Avtorstvo laboratorijskih postopkov in tehnoloških evalvacij
- Natančna in pravočasna obdelava vzorcev, prispevanje k interpretaciji rezultatov, priprava povzetkov predstavitev ter pravočasno dokumentiranje vseh podatkov v elektronskem laboratorijskem dnevniku in podatkovnih bazah
- Aktivno prevzemanje organizacijskih odgovornosti pri organizaciji laboratorija in pošiljkah, vključno z vzdrževanjem opreme in uvajanjem nove opreme
Minimalne zahteve – kaj prinašate v vlogo:
- Univerzitetna izobrazba / magisterij (MSc) s področja kemije, biokemije, kemijske tehnologije ali druge ustrezne discipline z najmanj 3 leti ustreznih delovnih izkušenj v industriji; ali Visokošolska izobrazba (BSc) s področja kemije, biokemije, kemijske tehnologije ali druge ustrezne discipline z najmanj 6 leti ustreznih delovnih izkušenj v industriji
- Dobro teoretično in močno praktično razumevanje na področju downstream procesiranja monoklonskih in multispecifičnih protiteles, vključno z večletnimi praktičnimi izkušnjami z Aekta tekočinsko kromatografijo, filtracijo in centrifugacijskimi tehnologijami
- Močne izkušnje z načrtovanjem eksperimentov in analizo podatkov
- Visoka sposobnost učenja za pridobivanje strokovnega znanja o novih tehnologijah in tehnični opremi
- Dokazane izkušnje z uspešnim določanjem prioritet in spoštovanjem časovnic
- Odprta in proaktivna komunikacija ter sposobnost sodelovanja z različnimi deležniki
- Zanesljiv in prilagodljiv timski igralec, vajen delitve nalog in projektov
- Tekoče znanje angleščine (ustno/pisno)
Zaželena znanja in spretnosti:
- Dobre izkušnje na enem od sorodnih področij (Upstream Processing in/ali fizikalno-kemijska proteinska analitika)
Benefits & Rewards
At Novartis, we’re committed to reimagining medicine together - and rewarding the people who make it happen.
Expected Annual Base Salary Range for role: €27,160 to € 50,440
The base salary offered is determined based on gender-neutral objectives, such as relevant skills, competencies and experience in accordance with the Novartis pay setting policy and upon joining Novartis will be reviewed periodically.
In addition to your base salary, you may be eligible for a performance-based bonus depending on certain performance parameters.
The rewards of being part of our team go far beyond base pay and incentives. We also offer a variety of competitive benefits in kind to help you thrive personally and professionally, such as insurance plans, retirement plans, wellbeing resources and global recognition programs. In addition, we provide flexible and hybrid working options, where possible, and minimum 14 weeks paid parental leave.
Pričakovani letni osnovni plačni razpon za delovno mesto: € 27,160 do € 50,440
Osnovna plača je določena glede na spolno nevtralne cilje, kot so relevantne veščine, kompetence in izkušnje v skladu s politiko plač Novartisa, ob vstopu v Novartis pa se redno pregleduje.
Poleg osnovne plače ste morda upravičeni do bonusa na podlagi uspešnosti, odvisno od določenih parametrov uspešnosti.
Nagrade, ki jih prinaša članstvo v naši ekipi, segajo daleč preko osnovne plače in spodbud. Ponujamo tudi različne konkurenčne ugodnosti v naravi, ki vam pomagajo uspevati osebno in poklicno, kot so zavarovalni načrti, pokojninski načrti, viri za dobro počutje in globalni programi priznanja. Poleg tega ponujamo prilagodljive in hibridne možnosti dela, kjer je mogoče, ter najmanj 14 tednov plačanega starševskega dopusta.
Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture
Benefits and Rewards: Learn about all the ways we’ll help you thrive personally and professionally.
Read our handbook (PDF 30 MB)
Accessibility and accommodation
Novartis is committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to perform the essential functions of a position, please send an e-mail to [email protected] and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
