Principal Scientist

Major accountabilities:

Onsite Role LI:#Onsite

Your responsibilities will include, but not limited to:

• Develop and validate targeted protein/peptide singleplex/multiplex biomarker assays by working in internal labs as well as guiding external lab partners.
• Implement (sample measurement and data transfer) validated biomarker assays in clinical studies.  Contribute/write quality reports and laboratory manuals.
• Generate and interpret data to enable proof of mechanism, dose selection & proof of biology across early clinical programs and present results at internal meetings.
• Providing subject matter expertise to lead, transition, implement and monitor immunoassay development and validation internally and at CROs.  Ensuring quality and timely delivery of data generated through outsourced activities.
• Empowered for experimental design, execution, interpretation and reporting (oral and written) of assigned projects under unbossed culture including innovative solutions with new technologies.  Cross train a variety of biomarker modalities and technologies.
• Design, execute and analyze untargeted profiling/multiplex assay data.  Develop and validate fit-for-purpose soluble biomarker solutions.
• As biomarker clinical expert in project teams, you will provide scientific and technical insights, contribute to the overall clinical study biomarker strategy and plan, lead the execution and support interpretation of biomarker data to enable proof of mechanism, proof of biology, safety and efficacy understanding and patient selection.
• As biomarker study lead in clinical studies, you will be accountable for the definition and execution of soluble biomarker plan and the successful implementation of internal and external “fit for purpose” biomarker assays with timely delivery of results.

The pay range for this position at commencement of employment is expected to be between $112,800 and $169,200/year; however, while salary ranges are effective from 1/1/24 through 12/31/24, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.
 

Minimum Requirements:

What you will bring to the role:

• MS in Biology, biochemistry or related discipline and must have a experience of 4-7 years of hands-on experience on Method development and validation with immunoassays in CROs or industry or Bachelors with 6+ years of experience in CROs or industry will be considered.  PhD with appropriate experience will also be considered. 
• Proficiency running variety of immunoassay platforms such as MSD, Luminex, Ella etc.  Experience with Quanterix Simoa, Mass Spectrometry, automated Western blots, Cobas is a plus.  Implement best practices for operation and maintenance of instrumentation. 
• Experience in troubleshooting of immunoassays and assay transfer to CROs.  Experience with multiplex assays and profiling platforms is highly desired.
• Experience working in a global organization and matrix-resourcing model.
• Good Computer skills (Excel, Word, PowerPoint, Soft MaxPro, SMART Book, Spotfire, GraphPad Prism, Watson LIMS).
• Understanding of regulatory requirement relevant to Biomarker Development (e.g. GCLP, ICH).
• Illustrated ability to be creative, self-motivated, willingness to accept responsibility, work collaboratively and independently.
• Good communication skills for oral and written in English.

Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture

Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Commitment to Diversity & Inclusion: The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

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