Principal Scientist - Toxicology

Key Responsibilities:

• Design and implement the early safety screening & profiling strategies, including those associated with secondary pharmacology, genetic toxicology and cardiovascular safety, in collaboration with internal and external partners.
• Give to early ADME-Tox data unification, harmonization, curation, and augmentation to support the Predictive Safety Strategy
• Effectively communicate with customers, including experimental design, data quality, timeline requirements and flowchart planning.
• Understand and implement agreed business strategy defined by local and global Preclinical Safety Profiling requirements, help to lead budget, ensuring appropriate coordination of projects.
• Participate in cross-functional early safety screening & profiling collaborations with Novartis Biomedical Research partners to support the early derisking of compounds, drug targets, and therapeutic modalities
• Deliver clear and concise presentations for audiences with different expertise
• In collaboration with cross-functional partners, provide scientific and strategic input to support the early derisking of compounds, drug targets, and therapeutic modalities
• Ensure quality and compliance of data generation, analyses and resultant reports

Essential Requirements:

• PhD with 2+ years or MVSc/MS/M.Pharm with 6+ years of relevant work experience in pharmacology / toxicology
• Understands the basic concepts of hazard identification and risk assessment associated with drug ADME, off-target mitigation, genetic toxicology, and cardiovascular safety.
• Familiar with early drug discovery processes
• Experience with data integrity and quality assurance practices.
• Excellent communication skills and ability to translate analytical concepts for diverse audience and collaborators (English is our primary language

Desirable Requirement:

• Articulates solutions /recommendations to business users. Presents analytical content concisely and effectively to non-technical team members and influences the outcome of predictive safety profiling contributions.
• Coordinates, prioritizes and efficiently allocates resources to critical initiatives: plans resources proactively, anticipates and actively manages change, sets stakeholder expectations as required, identifies operational risks and enable the team to drive issues to resolution, balances multiple priorities and minimizes surprise blocking issues.
• Collaborates with internal stakeholders, external partners, and cross-functional teams to solve critical business problems, propose operational efficiencies and innovative approaches.
• Familiar with visualization tools to increase efficiency and quality of the data communication and interpretation.
• Team player
• Strives for continuous learning (scientific and technical).

Commitment to Diversity & Inclusion: :

We are committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

Why Novartis: Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our
people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture

You’ll receive: You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook. https://www.novartis.com/careers/benefits-rewards

Commitment to Diversity and Inclusion:
Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network