## [TriCenter Gene Therapy Production in Durham, NC](/us-en/gene-therapy-production-tricenter-durham-north-carolina "TriCenter Gene Therapy Production in Durham, NC") ![Novartis Gene Therapy Production Durham North Carolina](/us-en/sites/novartis_us/files/styles/cta_image/public/2025-09/Durham%2C%20North%20Carolina.jpg.webp?itok=tCxUWkWk "Novartis Gene Therapy Production Durham North Carolina") Our TriCenter site in Durham, North Carolina is one of three sites that make up our Flagship Manufacturing Hub. With a focus on neuroscience treatments, the site makes, tests, and releases gene therapies. It also makes gene therapy products for ongoing and future clinical trials. We are also expanding its capabilities to support sterile filling of biologics into syringes and vials. ## Key Facts About the Site 2018 became a Novartis site 1 of 3 sites that comprise our #### North Carolina Manufacturing Hub ~280K square-foot site ## See Photos from Across Our North Carolina Flagship Manufacturing Hub Learn more about our recent groundbreaking in Durham, North Carolina, as well as our “Wall of Hands” at our gene therapy manufacturing facility: For every dose of gene therapy produced and shipped, a “handprint” is placed on the wall. Read the full story [here](https://www.novartis.com/us-en/stories/novartis-north-carolina-manufacturing-expansion). ## - ![Team shot at the groundbreaking, with shovels in sand. ](/us-en/sites/novartis_us/files/styles/image_gallery_full_width/public/2026-04/1.%20Ground%20Breaking%20Shot.jpg.webp?itok=Xv75-_kR "Team shot at the groundbreaking, with shovels in sand. ") View1/5 - ![Novartis CEO, Vas Narasimhan, and attendees at the groundbreaking of a North Carolina manufacturing site](/us-en/sites/novartis_us/files/styles/image_gallery_full_width/public/2026-04/Novartis%20CEO%2C%20Vas%20Narasimhan%2C%20and%20attendees%20at%20the%20groundbreaking%20of%20a%20North%20Carolina%20manufacturing%20site.jpg.webp?itok=2KQhcPxY "Novartis CEO, Vas Narasimhan, and attendees at the groundbreaking of a North Carolina manufacturing site") View2/5 - ![3 members of the Novartis team touring the groundbreaking site. ](/us-en/sites/novartis_us/files/styles/image_gallery_full_width/public/2026-04/photo%203-2%20%281%29.jpg.webp?itok=af4kHbX9 "3 members of the Novartis team touring the groundbreaking site. ") View3/5 - ![A bulldozer on the groundbreaking site.](/us-en/sites/novartis_us/files/styles/image_gallery_full_width/public/2026-04/2.%20Bulldozer.jpg.webp?itok=5WpA_VoK "A bulldozer on the groundbreaking site.") View4/5 - ![The “Wall of Hands” at our gene therapy manufacturing facility in Durham, NC. The paper hand prints represent doses of medicine shipped to patients.](/us-en/sites/novartis_us/files/styles/image_gallery_full_width/public/2026-04/Wall%20of%20hope%20blurred.png.webp?itok=zjZE89bh "The “Wall of Hands” at our gene therapy manufacturing facility in Durham, NC. The paper hand prints represent doses of medicine shipped to patients.") View5/5 ![Team shot at the groundbreaking, with shovels in sand. ](/us-en/sites/novartis_us/files/styles/image_gallery_full_width/public/2026-04/1.%20Ground%20Breaking%20Shot.jpg.webp?itok=Xv75-_kR "Team shot at the groundbreaking, with shovels in sand. ") **The groundbreaking of the North Carolina Flagship Manufacturing Hub:** Novartis CEO Vas Narasimhan, North Carolina Governor, Josh Stein, US Food and Drug Commissioner, Dr. Marty Makary at our 14TW site in Durham. 1/5 ![Novartis CEO, Vas Narasimhan, and attendees at the groundbreaking of a North Carolina manufacturing site](/us-en/sites/novartis_us/files/styles/image_gallery_full_width/public/2026-04/Novartis%20CEO%2C%20Vas%20Narasimhan%2C%20and%20attendees%20at%20the%20groundbreaking%20of%20a%20North%20Carolina%20manufacturing%20site.jpg.webp?itok=2KQhcPxY "Novartis CEO, Vas Narasimhan, and attendees at the groundbreaking of a North Carolina manufacturing site") **Celebrating progress in building our North Carolina Flagship Manufacturing Hub:** Attendees at the groundbreaking in Durham, NC. 2/5 ![3 members of the Novartis team touring the groundbreaking site. ](/us-en/sites/novartis_us/files/styles/image_gallery_full_width/public/2026-04/photo%203-2%20%281%29.jpg.webp?itok=af4kHbX9 "3 members of the Novartis team touring the groundbreaking site. ") **Touring the grounds at 14TW:** Novartis CEO Vas Narasimhan, US President Victor Bultó, and Senator Benton Sawrey, a North Carolina state representative, walking the grounds of the new Novartis site in Durham, NC. 3/5 ![A bulldozer on the groundbreaking site.](/us-en/sites/novartis_us/files/styles/image_gallery_full_width/public/2026-04/2.%20Bulldozer.jpg.webp?itok=5WpA_VoK "A bulldozer on the groundbreaking site.") **The big dig at 14TW:** Prepping to break ground on our expanding Flagship Manufacturing Hub in Durham, NC. 14TW is where biologics production will take place. The site will open in 2028. 4/5 ![The “Wall of Hands” at our gene therapy manufacturing facility in Durham, NC. The paper hand prints represent doses of medicine shipped to patients.](/us-en/sites/novartis_us/files/styles/image_gallery_full_width/public/2026-04/Wall%20of%20hope%20blurred.png.webp?itok=zjZE89bh "The “Wall of Hands” at our gene therapy manufacturing facility in Durham, NC. The paper hand prints represent doses of medicine shipped to patients.") **TriCenter Gene Therapy Production (Durham, NC):** The “Wall of Hands” at our gene therapy manufacturing facility. For every dose of medicine shipped, a paper handprint is placed on the wall as a visual reminder of our commitment to patients. 5/5 1. 2. 3. 4. 5. [ Previous](#paragraph--33116) [ Next](#paragraph--33116) ![scientists fist bumping ](/us-en/sites/novartis_us/files/styles/cta_image/public/2026-03/BJORN_NOVARTIS_RLT%20-%20Main%20Sequence%20RePurpose%202%20271025%20AM%20V1.00_00_58_12.Still029.jpg.webp?itok=1X4xkaL8 "Investing in America Hero") ## Explore Career Opportunities in Durham From science roles to manufacturing to business, find the right role at Novartis in the US and join us as we work to reimagine medicine. [Learn More](https://www.novartis.com/careers/career-search?search_api_fulltext=Durham&country%5B0%5D=LOC_US&field_job_posted_date=All&op=Submit&page= "Learn More") ## Featured Stories [ ![Portrait of Thierry Diagana, California Site Head for Novartis Biomedical Research, wearing black sweater and white collared shirt](/us-en/sites/novartis_us/files/styles/cards_1_3/public/2025-08/Q%26A_banner_v3_1.png.webp?itok=GMCshGUd "thierry-diagana-novartis-california-site-head-portrait") ### Designing for the Future: The Next Era of Biomedical Research in San Diego Thierry Diagana, California Sites Head at Novartis, shares the vision for a new research hub that will power future drug discovery. ](/us-en/stories/novartis-biomedical-research-hub-san-diego-thierry-diagana) [ ![Team shot at the groundbreaking, with shovels in sand. ](/us-en/sites/novartis_us/files/styles/cards_1_3/public/2026-04/1.%20Ground%20Breaking%20Shot.jpg.webp?itok=__w3U0mi "Team shot at the groundbreaking, with shovels in sand. ") ### Building for the Future: Novartis Expands Manufacturing Hub in North Carolina The creation of a 700,000-square-foot flagship manufacturing hub marks the continuation of our investment in the US, enabling us to more reliably reach patients across the country. ](/us-en/stories/novartis-north-carolina-manufacturing-expansion) [ ![neuron imagen](/us-en/sites/novartis_us/files/styles/cards_1_3/public/2026-02/neuron-image-from-novartis-sciart-collection.png%20%281%29.png.webp?itok=aJ6vlsYB "neuron image from novartis sciart collection") ### What's next in Neuroscience drug discovery A Q&A with Bryan Laffitte, who leads a Novartis team that’s using the tools of genetic medicine to innovate new therapies for neuromuscular and neurodegenerative conditions. ](/us-en/stories/whats-next-neuroscience-drug-discovery-conversation-genetic-medicine-head-bryan-laffitte) ## Latest News [Dec 12, 2025 - Media Release ### Novartis breaks ground on flagship manufacturing hub in North Carolina ](/us-en/news/media-releases/novartis-breaks-ground-flagship-manufacturing-hub-north-carolina) [Nov 19, 2025 - Media Release ### Novartis announces plans to build flagship manufacturing hub in North Carolina ](/us-en/news/media-releases/novartis-announces-plans-build-flagship-manufacturing-hub-north-carolina) [Apr 10, 2025 - Media Release ### Novartis plans to expand its US-based manufacturing and R&D footprint with a total investment of $23B over the next 5 years ](/us-en/news/media-releases/novartis-plans-expand-its-us-based-manufacturing-and-rd-footprint-total-investment-23b-over-next-5-years) [View More](https://www.novartis.com/us-en/news/news-archive "View More") ## See Our Other US Sites Previous Next [ ![Biomedical Research organization in Cambridge, Massachusetts](/us-en/sites/novartis_us/files/styles/cards_1_3/public/2025-09/Biomedical-Research-organization-in-Cambridge-Massachusetts.png.webp?itok=5KRHlit5 "Biomedical-Research-organization-in-Cambridge-Massachusetts") ### Cambridge, MA This Biomedical Research organization, established in 2003, is dedicated to scientific innovation and drug discovery. ](https://www.novartis.com/us-en/biomedical-research-organization-cambridge-ma) [ ![Novartis Radioligand Therapy Production Carlsbad California](/us-en/sites/novartis_us/files/styles/cards_1_3/public/2025-09/Carlsbad%2C%20California.JPG.webp?itok=GzVy9Yv3 "Novartis Radioligand Therapy Production Carlsbad California") ### Carlsbad, CA Our third US radioligand therapy manufacturing site opened in 2025 and serves patients across the western US, Alaska and Hawaii. ](https://www.novartis.com/us-en/radioligand-therapy-production-carlsbad-ca) [ ![Scientist working in a laboratory with test tubes and scientific equipment](/us-en/sites/novartis_us/files/styles/cards_1_3/public/2026-04/Scientist%20working%20in%20a%20laboratory%20with%20test%20tubes%20and%20scientific%20equipment.jpeg.webp?itok=OKKyXm55 "Scientist working in a laboratory with test tubes and scientific equipment") ### Denton, TX Expected to become fully operational in 2028, our fifth US radioligand manufacturing site will serve patients in the southern US. ](https://www.novartis.com/us-en/radioligand-therapy-production-denton-tx) [ ![Novartis Gene Therapy Production Durham, North Carolina](/us-en/sites/novartis_us/files/styles/cards_1_3/public/2025-12/Durham%2C%20North%20Carolina.jpg.webp?itok=DUwFq60z "Novartis Gene Therapy Production Durham, North Carolina") ### Durham, NC (14TW) Expected to be operational in 2028, the site will house two new facilities for manufacturing biologics and sterile packaging. ](https://www.novartis.com/us-en/14tw-biologics-production-durham-nc) [ ![Novartis Radioligand Therapy Production Indianapolis Indiana](/us-en/sites/novartis_us/files/styles/cards_1_3/public/2025-09/Indianapolis%2C%20Indiana_0.jpg.webp?itok=LXoGnbGT "Novartis Radioligand Therapy Production Indianapolis Indiana") ### Indianapolis, IN Our second US radioligand therapy manufacturing site opened in 2024. Expansion of the site is ongoing. ](https://www.novartis.com/us-en/radioligand-therapy-production-indianapolis) [ ![Novartis Radioligand Therapy Production Millburn New Jersey](/us-en/sites/novartis_us/files/styles/cards_1_3/public/2025-09/Millburn%2C%20New%20Jersey.JPG.webp?itok=hXJ9CeAC "Novartis Radioligand Therapy Production Millburn New Jersey") ### Millburn, NJ Our first US radioligand therapy manufacturing site opened in 2023. Its on-site production capabilities continue to expand. ](https://www.novartis.com/us-en/radioligand-therapy-production-millburn) [ ![Morrisville, North Carolina](/us-en/sites/novartis_us/files/styles/cards_1_3/public/2026-04/Morrisville%2C%20NC_0.jpg.webp?itok=rCf5foqp "Morrisville, North Carolina") ### Morrisville, NC Two new facilities for production and packaging of small molecule medicines, and active pharmaceutical ingredient manufacturing. ](https://www.novartis.com/us-en/small-molecule-production-morrisville-nc) [ ![Novartis Cell Therapy Production Morris Plains New Jersey ](/us-en/sites/novartis_us/files/styles/cards_1_3/public/2025-09/Morris%20Plains%2C%20New%20Jersey_0.jpg.webp?itok=vYv-K-wX " Novartis Cell Therapy Production Morris Plains New Jersey") ### Morris Plains, NJ Since 2015, the site has specialized in the production of groundbreaking cell therapies. ](https://www.novartis.com/us-en/cell-therapy-production-morris-plains) [ ![Novartis Biomedical Research Center in San Diego, California](/us-en/sites/novartis_us/files/styles/cards_1_3/public/2026-02/Novartis-Biomedical-Research-Center-San-Diego-California.jpg.webp?itok=sGR7oWTC "Novartis Biomedical Research Center in San Diego, California") ### San Diego, CA In 2026, we broke ground on a new global Biomedical Research center designed to accelerate drug discovery. ](https://www.novartis.com/us-en/biomedical-research-center-san-diego-ca) [ ![radioligand therapy manufacturing facility in Winter Park, Florida](/us-en/sites/novartis_us/files/styles/cards_1_3/public/2026-01/Radioligand%20therapy%20manufacturing%20facility%20in%20Winter%20Park%2C%20Florida.jpg.webp?itok=PNmbu9zy "radioligand therapy manufacturing facility in Winter Park, Florida") ### Winter Park, FL Expected to open in 2029, our fourth US radioligand manufacturing site will optimize delivery for patients across the southeastern US. ](https://www.novartis.com/us-en/rlt-therapy-production-winter-park) ### Learn More About Our Investment in the US [Return to Investing in America’s Health](https://www.novartis.com/us-en/about/investing-americas-health "Return to Investing in America’s Health")