Our muscles are made up of fibers, which form during a multi-step process. One of the steps critical to this process is cell fusion. Scientists on a quest to restore strength to patients with muscle deficiencies—including researchers in the Musculoskeletal Diseases group at the Novartis Institutes for BioMedical Research—study fusion dynamics. For example, they are able to determine where in the cell particular proteins reside. In the image above, a protein stained with an antibody that emits a green color appears at cell-cell junctions, suggesting that it might be important for fusion. This type of experiment enhances the team’s understanding of the mechanism of action of their target and helps facilitate the drug discovery process.