Mitochondria are critical for life, but genetic and environmental factors cause dysfunction, leading to disease. We wish to improve mitochondrial function in cellular models of mitochondrial disorders. One pathway that we are currently studying in depth is the PINK-Parkin mitophagy pathway, the major pathway implicated in the clearance of damaged mitochondria. Using a genome-wide siRNA screen, we have isolated a large number of genes that alter Parkin recruitment to damaged mitochondria, and a major goal of our research is to elucidate the molecular role of these genes in mitophagy. In particular we would like to understand the behaviour of mitochondria in relation to the alteration of these genes in in vitro models of mitochondrial disorders.