T and B lymphocytes are critical players in multiple autoimmune disorders. My research activities have focused on investigating the relevance of various signaling nodes and pathways downstream of major immunoreceptors (e.g., TCR, BCR, activating and inhibitory receptors, etc.) in both T cells and B cells and to use this information to design new therapeutic approaches aimed at inhibiting pathogenic immune responses.
Our laboratory relies on the use of a wide array of cellular in vitro techniques, functional assays (human, rat or mouse cells), animal models and multicolor flow cytometry analyses to assess the effect of drug candidates (biologics and low molecular weight compounds) on various adaptive and innate immune cell subsets. Our research also involves the generation and detailed characterization of genetically modified animals to investigate the in vivo biological relevance of novel drug targets. Given the importance of immune cells in anti-tumor immunity, we are also using our knowledge to develop innovative drugs aiming at boosting immune responses to cancer.