Encoded chemical libraries represent a new technology pushing the limits of lead generation in drug discovery. A huge diversity of organic molecules can be synthesized efficiently where each individual molecule carries a unique oligonucleotide tag serving as amplifiable barcode. The oligonucleotide tag provides single-molecule detection by allowing amplification and sequencing for hit identification from in-vitro affinity screening of encoded libraries of immense diversity. We want to further evolve the technology by combining encoded chemistry with complementary lead discovery approaches.
Our research interests include:
(1) Proof-of-concept for combining complementary lead discovery methods in synergy with novel encoded chemistry. (2) Designing, synthesizing, and screening of a oligonucleotide-tagged library to increase our understanding of efficient target modulation. (3) Leveraging the results from oligonucleotide-encoded screening by synthesizing corresponding bioactive small molecules that can modulate protein function.