2017
Autophagy-independent lysosomal targeting regulated by ULK1/2-FIP200 and ATG9.
Goodwin JM, Dowdle WE, DeJesus R, Wang Z, Bergman P, Kobylarz M, Lindeman A, Xavier RJ, McAllister G, Nyfeler B, Hoffman G, Murphy LO.
Cell Rep. 2017 Sep 5;20(10):2341-2356.
Inverting conventional chemoselectivity in Pd-catalyzed amine arylations with multiply halogenated pyridines.
Keylor MH, Niemeyer ZL, Sigman MS, Tan KL.
J Am Chem Soc. 2017 Aug 9;139(31):10613-10616.
Reverse translation of adverse event reports paves the way for de-risking preclinical off-targets.
Maciejewski M, Lounkine E, Whitebread S, Farmer P, DuMouchel W, Shoichet BK, Urban L.
Elife. 2017 Aug 8;6. pii: e25818.
Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation.
Wlodarska M, Luo C, Kolde R, d'Hennezel E, Annand JW, Heim CE, Krastel P, Schmitt EK, Omar AS, Creasey EA, Garner AL, Mohammadi S, O'Connell DJ, Abubucker S, Arthur TD, Franzosa EA, Huttenhower C, Murphy LO, Haiser HJ, Vlamakis H, Porter JA, Xavier RJ.
Cell Host Microbe. 2017 Jul 12;22(1):25-37.
A multi-scale convolutional neural network for phenotyping high-content cellular images.
Godinez WJ, Hossain I, Lazic SE, Davies JW, Zhang X.
Bioinformatics. 2017 Jul 1;33(13):2010-2019.
The SIAH E3 ubiquitin ligases promote Wnt/β-catenin signaling through mediating Wnt-induced Axin degradation.
Ji L, Jiang B, Jiang X, Charlat O, Chen A, Mickanin C, Bauer A, Xu W, Yan X, Cong F.
Genes Dev. 2017 May 1;31(9):904-915.
Structure-kinetic relationships of passive membrane permeation from multiscale modeling.
Dickson CJ, Hornak V, Pearlstein RA, Duca JS.
J Am Chem Soc. 2017 Jan 11;139(1):442-452.