## [Sjögren’s disease](/diseases/sjogrens-disease "Sjögren’s disease") ![Two smiling female friends chatting on a sofa](/sites/novartis_com/files/styles/crop_freeform/public/2025-10/two-friends-chatting-on-sofa.jpg.webp?itok=RA2lCj6V "Friends chatting") Fictional patient image## What is Sjögren’s disease? Sjögren’s disease is a serious, progressive, systemic autoimmune disease, meaning it can affect the entire body rather than just one area.1-4 It affects glands that release secretions, such as tears and saliva, causing dryness, and also affects multiple organs and systems, causing inflammation and tissue damage, impacting the entire body.3,5-7 - In some geographies, it affects approximately 0.25% of the population3,8 - Global incidence and prevalence rates are often underestimated due to underdiagnosis and misdiagnosis due to nonspecific symptoms2,3,8-10 - It is 9 times more common in women than men2 - In some geographies, an estimated 50% of patients remain undiagnosed3,8 - It is considered the second most prevalent rheumatic disease1 ## About the condition ### What are the symptoms of Sjögren’s disease? Beyond the more easily recognizable symptoms, such as excessive dry eyes and mouth, over 9 out of 10 patients report experiencing at least one other systemic symptom of Sjögren’s.11 These can affect many parts of the body, including:2,4,12-16 - Joints, causing chronic pain - Nerves, causing numbness or memory issues - Lungs, with scarring in about 1 in 5 patients - Kidneys, with inflammation in about 1 in 3 patients - Increased risk of developing lymphoma – a type of cancer - Severe fatigue As Sjögren’s can affect so many organs, it is now seen as a full-body, or systemic disease – not just one that causes dryness.4 Patients may also experience neurological symptoms, with almost 4 out of every 10 patients reporting ‘brain fog’, referring to slowed thinking, poor concentration and slowed responses.11 ### How does the immune system dysfunction cause Sjögren's symptoms? Sjögren’s is a B cell–driven disease in which overactive B cells infiltrate, target and attack parts of the body, producing autoantibodies and antibodies that cause inflammation and damage.5-7 The abnormal B cells and the autoantibodies cause inflammation and dysfunction of certain glands, leading to the characteristic symptoms of dry eyes and dry mouth. The inflammation can also happen in other organs and tissues in the body, resulting in wider systemic complications.6,16 As B cells are thought to play a key role in Sjögren’s, a therapy that can effectively target B cells can potentially reduce the disease burden.7 ### What impact does Sjögren’s have on everyday life? The considerable discomfort and limitations caused by Sjögren’s can result in a decline in physical, mental, and social wellbeing.4,9,11,15 In fact, in a recent study exploring the experiences of people living with Sjögren’s:11 - 58% of people reported a high impact on emotional well-being. - 48% of people documented that their daily activities were widely affected by the condition - 47% shared that their work was impacted. Ana Vieira, who lives with Sjögren’s and is also the Vice President of Sjögren Europe, shares how the disease affects her working life and its emotional impact. > The disease has a massive impact in my professional life. Because there is brain fog, difficulties in concentration, difficulties in speech, slow thinking, forgetfulness, and there is this whole graveyard of unmet timelines. So, you don’t deliver as you are expected. And this generates a massive emotional impact. Watch the full video below to learn more about Ana’s personal journey of living and working with Sjögren’s. var kPlayer = KalturaPlayer_55802022 || KalturaPlayer; var config = { targetId: "kaltura_player_6a9e56b03db22396197020", provider: { widgetId: "1_61f4ehfr", partnerId: "2076321", uiConfId: "55802022" }, playback: { autoplay: false, autopause: false, muted: false, loop: false }, sources: { options: {}, startTime: 0 }, disableUserCache: "true", plugins: {}, sources: { options: {}, startTime: 0 }, ui: { showCCButton: false, settings: { showQualityMenu: true, showSpeedMenu: false }, components: { fullscreen: { disableDoubleClick: false } }, uiComponents: [ { presets: ['Playback', 'Live'], area: 'BottomBarRightControls', replaceComponent: 'Fullscreen', get: kPlayer.ui.components.Remove } ] } }; // Check and add plugins only if they exist if (kPlayer.plugins["download"]) { config.plugins.download = { disable: true }; } if (kPlayer.plugins["transcript"]) { config.plugins["playkit-js-transcript"] = { position: "right", // Default: bottom;('left', 'right', 'top', 'bottom') to enable transcript. expandMode: "over", // Default: alongside;('alongside', 'hidden', 'over') expandOnFirstPlay: false, showTime: true, downloadDisabled: false, printDisabled: false, disable: true }; } if (kPlayer.plugins["preventSeek"]) { config.plugins.preventSeek = { preventSeekForward: false, preventSeek: false }; } config.plugins.floating = { disable: true }; if (kPlayer.plugins["navigation"]) { config.plugins.navigation = { position: "right", expandMode: "over", expandOnFirstPlay: false, visible: false }; } if (kPlayer.plugins["hotspots"]) { config.plugins['playkit-js-hotspots'] = { disable: true }; } if (kPlayer.plugins["moderation"]) { config.plugins['playkit-js-moderation'] = { disable: true }; } if (kPlayer.plugins["info"]) { config.plugins['playkit-js-info'] = { disable: true }; } if (kPlayer.plugins["share"]) { config.plugins.share = { disable: true }; } config.ui.uiComponents = []; config.abr = { "enabled": false, "restrictions": { "minBitrate": 1925000 } }; if (kPlayer.plugins["googleAnalytics"]) { config.plugins.googleTagManager = {}; config.plugins.googleTagManager.customEventsTracking = {}; config.plugins.googleTagManager.containerId = 'GTM-57RJQ5'; config.plugins.googleTagManager.customEventsTracking.custom = []; config.plugins.googleTagManager.customEventsTracking = { preset: { coreEvents: true, UIEvents: false, playlistEvents: false, castEvents: false } }; } // Ensure the global player registry array always exists, regardless of embed type. window.kalturaPlayerVideos = window.kalturaPlayerVideos || []; try { var thumbEmbedPromise = __thumbnailEmbed({config, mediaInfo: {entryId: "1_de386h7x"}}); // __thumbnailEmbed() returns a Promise that resolves with the player instance // when the user clicks the thumbnail. Use .then() to capture the player directly. thumbEmbedPromise .then(function(player) { window.kalturaPlayerVideos.push(player); // Notify kaltura_datalayer.js that a new player is ready so it can // attach custom event listeners immediately, regardless of when // the user clicked the thumbnail relative to page load. document.dispatchEvent(new CustomEvent('kalturaPlayerReady', { detail: { player: player } })); }) .catch(function(error) { console.error(error); }); } catch (e) { console.error(e.message) } ### Why is Sjögren’s often difficult to diagnose? Because Sjögren’s can show up in many different ways and affect multiple parts of the body, it’s often missed or mistaken for something else.9,10 This means people may wait a long time before getting the right diagnosis and treatment, which can make their symptoms worse and delay proper care.3,9,10,17 The mean age at diagnosis ranges from 52 to 62 years.18 Sjögren’s is 9 times more common in women than men.2 While researchers are not certain why more women than men develop Sjögren’s, they are investigating genetic, hormonal, and environmental factors.19 ### How is Sjögren’s currently managed? Sjögren's management continues to focus on relieving symptoms rather than getting to the underlying systemic causes.4 This often only provides temporary and partial symptomatic relief, highlighting the need for effective disease-modifying treatment.4,20 Reflecting these limitations, in a recent study:11,21 - 94% of patients living with Sjögren’s were not fully satisfied with the available range of therapies - Preventing disease worsening is a main treatment goal for people with Sjögren’s ### What are some questions you can ask your doctor? 1. How should I track my symptoms between appointments? 2. How might Sjögren’s affect my health over time? 3. How might Sjögren’s affect different parts of my body beyond dryness? 4. What warning signs or symptoms should I watch for, and when should I seek help quickly or urgently? 5. Where can I find trusted information and support for people with Sjögren’s? ## Hear from the Sjögren’s community: > Sjögren's is very difficult to live with. You don't realise how much of your body is involved. It's a serious systemic disease that's not taken seriously enough, and it does progress over time. Eyes are impacted, teeth are impacted, and it can hit any organ system in the body. > > **Linda Stone**, Sjögren’s UK ### Patient support and resources For more information about Sjögren’s and managing symptoms, find your local member of the International Sjögren’s Network here: Glossary **Antibodies** - Proteins made by the immune system that help recognise and fight germs such as bacteria and viruses. They attach to substances that do not belong in the body so the immune system can remove them. **Autoantibodies** – Proteins produced by your immune system that mistakenly target and attack your body’s own healthy cells, tissues or organs. **Autoimmune** – A condition where the body’s immune system mistakenly attacks its own healthy cells and tissues, rather than protecting them. **B cells** - A type of white blood cell that helps protect the body by making antibodies. B cells play an important role in the immune system. **Dryness** - A lack of normal moisture in parts of the body, such as the eyes or mouth, which can cause discomfort, irritation, or difficulty with everyday activities like eating or blinking. **Fatigue** - A feeling of extreme tiredness or exhaustion that does not improve much with rest and can make everyday activities difficult. It can affect both physical and mental energy. **Joint pain** - Discomfort, aching, or soreness in the joints, such as the knees, hips, or hands, which may make movement difficult. **Rheumatic disease** - A group of conditions that affect the joints, muscles or connective tissues and often cause pain, stiffness and inflammation. **Systemic disease** - A condition that can affect multiple organs or body systems, rather than just one part of the body. **Tissue damage** - Harm or injury to the body’s tissues, which can occur over time due to inflammation or disease and may affect how organs work. **References:** 1. The National Academies of Sciences, Engineering, and Medicine. Selected Immune Disorders and Disability. Washington, DC: The National Academies Press. 2022. 2. Mariette X, Criswell LA. Primary Sjögren's Syndrome. N Engl J Med 2018; 378(10): 931–939. 3. Juan Camilo Sarmiento-Monroy RDM, Adriana Rojas-Villarraga, and Juan-Manuel Anaya. Sjögren’s syndrome. In: Anaya JM, Shoenfeld Y, Rojas-Villarraga A, eds. Autoimmunity: From Bench to Bedside. Bogota: El Rosario University Press; 2013. 4. Vitali C, Minniti A, Pignataro F, et al. Management of Sjögren's Syndrome: Present Issues and Future Perspectives. Front Med (Lausanne) 2021; 8: 676885. 5. Lee AY, Qi Z, Jackson KJ, et al. Self-reactive B cells are increased in all major stages of peripheral development in Sjögren's disease. Immunol Cell Biol 2025; 103(4): 401–410. 6. Both T, Dalm VA, van Hagen PM, et al. Reviewing primary Sjögren's syndrome: beyond the dryness - From pathophysiology to diagnosis and treatment. Int J Med Sci 2017; 14: 191-200. 7. Cornec D, Devauchelle-Pensec V, Tobón GJ, et al. B cells in Sjögren's syndrome: from pathophysiology to diagnosis and treatment. J Autoimmun 2012; 39(3): 161–167. 8. Narváez J, Sánchez-Fernández S, Seoane-Mato D, et al. Prevalence of Sjögren's syndrome in the general adult population in Spain: estimating the proportion of undiagnosed cases. Sci Rep 2020; 10: 10627. 9. Parisis D, Chivasso C, Perret J, et al. Current State of Knowledge on Primary Sjögren's Syndrome, an Autoimmune Exocrinopathy. J Clin Med 2020; 9(7): 2299. 10. Thurtle E, Grosjean A, Steenackers M, et al. Epidemiology of Sjögren's: A Systematic Literature Review. Rheumatol Ther 2024; 11(1): 1–17. 11. Marvel J, Kenney G, Church J, et al. Spotlight on Sjögren's: a patient perspective on burden of illness and unmet needs - results from a real-world survey. RMD Open 2026; 12: e006166. 12. Luppi F, Sebastiani M, Silva M, et al. Interstitial lung disease in Sjögren's syndrome: a clinical review. Clin Exp Rheumatol 2020; 38 Suppl 126: 291-300. 13. Chatterjee R, Balakrishnan A, Kharbanda R, et al. Renal involvement in Sjőgren's syndrome: predictors and impact on patient outcomes. Rheumatol Int 2023; 43: 1297-1306. 14. Longhino S, Chatzis LG, Dal Pozzolo R, et al. Sjögren's syndrome: one year in review 2023. Clin Exp Rheumatol 2023; 41: 2343-2356. 15. McCoy SS, Bartels CM, Saldanha IJ, et al. National Sjögren's Foundation Survey: Burden of Oral and Systemic Involvement on Quality of Life. J Rheumatol 2021; 48: 1029-1036. 16. Carr AJ, Ng WF, Figueiredo F, et al. Sjögren's syndrome – an update for dental practitioners. British Dental Journal 2012; 213: 353-357. 17. Meinecke A, Kreis K, Olson P, et al. Impact of time to diagnosis in patients with primary Sjögren's syndrome: a cross-sectional study. Clin Exp Rheumatol 2024; 42: 2444-2452. 18. Negrini S, Emmi G, Greco M, et al. Sjögren's syndrome: a systemic autoimmune disease. Clin Exp Med 2022; 22(1): 9–25. 19. Brandt JE, Priori R, Valesini G, et al. Sex differences in Sjögren's syndrome: a comprehensive review of immune mechanisms. Biol Sex Differ 2015; 6: 19. 20. Ramos-Casals M, Brito-Zerón P, Bombardieri S, et al. EULAR recommendations for the management of Sjögren's syndrome with topical and systemic therapies. Ann Rheum Dis 2020; 79(1): 3–18. 21. Marvel J, Kenney G, Church J, et al. Real-World Insights into the Treatment Satisfaction and Unmet Needs of Sjögren's Disease: A Patient-Centred Analysis. Presented as an abstract at EULAR European Congress of Rheumatology 2025; June 11-14, 2025; Barcelona, Spain.