Last Update: Jul 30, 2026 A Single Arm, Multicenter, Open-label Extension (OLE) Trial to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230) in Participants Who Completed the Parent Lp(a)HORIZON Trial ClinicalTrials.gov Identifier: [NCT07517263](https://clinicaltrials.gov/ct2/show/NCT07517263) Novartis Reference Number:CTQJ230A12301E1 [See if you Pre-qualify](#trial-eligibility "See if you Pre-qualify") All compounds are either investigational or being studied for (a) new use(s). Efficacy and safety have not been established. There is no guarantee that they will become commercially available for the use(s) under investigation. ## Study Description This open-label extension study will provide post-trial access to pelacarsen (TQJ230) to participants who have successfully completed the double-blind parent study (CTQJ230A12301). This study will evaluate long-term safety and tolerability of pelacarsen (TQJ230) 80 mg Once a month (QM) in participants with established cardiovascular disease and elevated Lp(a) who completed the parent study (CTQJ230A12301). Condition Cardiovascular Disease and Lipoprotein(a) Phase Phase3 Overall Status Recruiting Number of Participants5700 Start Date May 11, 2026 Completion Date Jan 09, 2030 Gender All Age(s) 18 Years - 100 Years (Adult, Older Adult) ## Interventions Drug ### Pelacarsen (TQJ230) pelacarsen 80mg s.c. monthly ## Eligibility Criteria Inclusion Criteria: \* Participants who have provided informed consent prior to initiation of any study-specific activities/procedures. \* Participants who have completed the parent study EOS visit while still on assigned investigational product. Exclusion Criteria: \* Participants who for any reason permanently discontinued or have interrupted the investigational product for continuous 6 months at EOS during the parent study. \* Participants who have a history or evidence of any clinically significant disorder, condition, or disease that in the opinion of the investigator or Novartis physician (if consulted), would put the participant at risk or interfere with the study participation, including, but not restricted to conditions outlined in Table 6-3 and Table 6-5. \* Participants are receiving another investigational drug or device before the open-label treatment period. \* Participants have a known sensitivity to the study drug and are deemed as unsuited for the study by the Investigator at Screening visit. Other protocol-defined inclusion/exclusion criteria may apply. 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States ###### Eveline O Stock ###### Liliann Zou Phone: [+1 415 514 0992]() Email: #### Helping Hands Medical Associates INC Recruiting Santa Ana,California,92704,United States Phone: [+1 714 662 2900]() #### Manshadi Heart Institute Recruiting Stockton,California,95204,United States ###### Delaina Sanguinetti Email: ###### Ramin Manshadi #### Interv Cardiology Med Grp Recruiting West Hills,California,91307,United States ###### Farhad Rafii ###### Michael Fam Phone: [+1 818 235 7104]() Email: #### Wake Forest University Baptist Medical Center Recruiting Winston-Salem,North Carolina,27157,United States ###### Ginger Leonard Phone: [+1 336 885 6168]() Email: ###### Herman Barrett Cheek ###### Keishia Rodriguez Phone: [+1 336 716 3775]() Email: ###### Michael Shapiro #### Cardiology Consultants of Philadelphia Recruiting Yardley,Pennsylvania,19067,United States ###### Paul Grena ###### Sharon Budzinski Phone: [+1 215 321 7400#242]() Email: #### Virginia Heart Recruiting Falls 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Knepper Email: ###### Marjan U Mujib #### Monument Health Clinical Research Recruiting Rapid City,South Dakota,57701,United States ###### Chelsie Taylor Phone: [+1 605 755 4326]() Email: ###### Stephen Wasemiller #### The Stern Cardiovascular Foundation Recruiting Germantown,Tennessee,38138,United States ###### Frank Augustus McGrew ###### Rishi Bhula Phone: [+1 901 271 4063]() Email: #### Cardiovascular Res of Knoxville LLC Recruiting Powell,Tennessee,37849,United States ###### Charles B Treasure ###### Thea Baker Phone: [+1 865 523 9006]() Email: #### Soltero Cardiovascular Research Center Recruiting Dallas,Texas,75226,United States ###### Cara East ###### Merielle Boatman Phone: [+1 214 820 2273]() Email: #### North Texas Endocrine Center Recruiting Dallas,Texas,75231,United States ###### Anusha Haidry Phone: [+1 214 369 5992]() Email: ###### Peter Bressler #### SW Family Medicine Associates Recruiting Dallas,Texas,75235,United States ###### Chrisette Dharma ###### Nikhila 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