Last Update: Jul 20, 2026 A Real-world Chronic Myelogenous Leukemia (CML) Patient Disease Registry to Describe Patient Experience and Clinical Outcomes Among Patients With CML Receiving Approved First or Second Line Tyrosine Kinase Inhibitor (TKI) Therapy ClinicalTrials.gov Identifier: [NCT07091019](https://clinicaltrials.gov/ct2/show/NCT07091019) Novartis Reference Number:CABL001J1US01 [See if you Pre-qualify](#trial-eligibility "See if you Pre-qualify") All compounds are either investigational or being studied for (a) new use(s). Efficacy and safety have not been established. There is no guarantee that they will become commercially available for the use(s) under investigation. ## Study Description This CML disease registry (ASC4REAL-2) aims to gather evidence on the tolerability, safety, effectiveness, and patient-reported outcomes (PRO) in real-world healthcare from patients with Ph+-CML-CP treated with TKIs approved for 1L and 2L, including prospective follow-up for 5 years identifying and describing long-term treatment outcomes. Condition Chronic Myelogenous Leukemia - Chronic Phase Overall Status Recruiting Number of Participants1000 Start Date Dec 17, 2025 Completion Date Apr 20, 2033 Gender All Age(s) 18 Years - 100 Years (Adult, Older Adult) ## Interventions Other ### TKIs There is no treatment allocation for NIS trials. Patients administered TKI (asciminib, bosutinib, dasatinib, imatinib, nilotinib) by prescription will be enrolled. ## Eligibility Criteria Inclusion Criteria: \* 18 years or older at the time of Ph+-CML-CP diagnosis. \* Receiving TKI treatment (asciminib, bosutinib, dasatinib, imatinib, or nilotinib) in routine medical care either as initial therapy or after 1 prior TKI therapy. \* Receiving treatment at US and US territories (i.e., Puerto Rico) medical practice (e.g. community-based, office-based, hospital-based, academic). \* Signed informed consent form (ICF) prior to participation in the study including agreement to be tokenized so that the patient's anonymized RWD (EMRs and/or claims data) can be accessed. Exclusion Criteria: \* Active participation in an interventional trial that may influence the management of their Ph+-CML-CP disease. \* Currently being treated with a CML TKI in 3L or beyond. \* Known presence of T315I mutation. \* Currently in TFR phase and are not on active CML TKI therapy. \* Previously received treatment with a prior stem cell transplant \* Pregnant or nursing (lactating) female. United States #### Avera Cancer Recruiting Sioux Falls,South Dakota,57105,United States ###### Tiffani Kirkpatrick Phone: [+1 605 322 3064]() #### Truman Medical Center Recruiting Kansas City,Missouri,64108,United States ###### Anuj Shrestha #### Cancer Care Specialists of Central Illinois Recruiting Decatur,Illinois,62526,United States ###### James Wade #### MultiCare Health System Institute Recruiting Tacoma,Washington,98405,United States ###### Nehal Masood ###### Ali Dadla Phone: [+1 253 428 8756]() Phone: [+1 253 403 5265]() #### Fred Hutchinson Cancer Research Center Recruiting Seattle,Washington,98109-1024,United States ###### Vivian Oehler Phone: [+1 206 667 7315]() #### Baylor Scott and White Research Recruiting Temple,Texas,76502,United States ###### Lucas Wong Phone: [+1 254 935 5838]() #### University of Alabama at Birmingham Recruiting Birmingham,Alabama,35233-0271,United States Phone: [+1 205 502 9967]() ###### Omer Jamy #### Oregon Oncology Specialists Salem Recruiting Salem,Oregon,97301,United States ###### John Strother #### Tri-County Hematology and Oncology Associates Recruiting Canton,Ohio,44718,United States ###### Norman Rafique #### SUNY Upstate Medical University Recruiting Syracuse,New York,13210,United States ###### Gillian Kupakuwana-Suk #### NY Cancer and Blood Specialists Recruiting East Setauket,New York,11733,United States ###### Adam Hines #### St Agnes Hospital Recruiting Baltimore,Maryland,21229,United States ###### Carole Miller Phone: [+1 410 368 3412]() #### Sacred Heart Medical Oncology Recruiting Pensacola,Florida,32504,United States ###### Dany El-Sayah Phone: [+1 850 416 2730]() #### Stamford Hospital Recruiting Stamford,Connecticut,06902,United States ###### Joshua Dower #### Lundquist Inst BioMed at Harbor Recruiting Torrance,California,90509-2910,United States ###### Sarah Elizabeth Tomassetti #### Stockton Hematology Oncology Medical Group Inc Recruiting Stockton,California,95204,United States ###### Ravleen Grewal Phone: [+1 209 466 2626]() ## Worldwide Contacts If the location of your choosing does not feature any contact detail, please reach out using the information below. #### Novartis Pharmaceuticals Phone: [ 1-888-669-6682](tel:1-888-669-6682) Email: