Last Update: Aug 19, 2026 A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase II Platform Study to Assess the Efficacy and Safety of Investigational Compound(s) in Patients With Moderate to Severe Atopic Dermatitis ClinicalTrials.gov Identifier: [NCT06947993](https://clinicaltrials.gov/ct2/show/NCT06947993) Novartis Reference Number:CADPT17A12201 [See if you Pre-qualify](#trial-eligibility "See if you Pre-qualify") All compounds are either investigational or being studied for (a) new use(s). Efficacy and safety have not been established. There is no guarantee that they will become commercially available for the use(s) under investigation. ## Study Description This trial is designed to evaluate multiple compounds in participants with moderate to severe atopic dermatitis (AD). This is a multicenter, randomized, double-blind, placebo-controlled Phase II platform study to investigate the efficacy and safety of several interventions in participants with moderate to severe AD. The first intervention planned to be evaluated is GHZ339. Participants will be randomly assigned to one of the study arms. Condition Atopic Dermatitis Phase Phase2 Overall Status Recruiting Number of Participants224 Start Date May 16, 2025 Completion Date Dec 22, 2028 Gender All Age(s) 18 Years - 100 Years (Adult, Older Adult) ## Interventions Drug ### GHZ339 GHZ339 administered at dose A, B, C and D Drug ### Placebo Matching placebo ## Eligibility Criteria Key Inclusion Criteria of the master protocol: \* Able and willing to sign the informed consent (IC) \* Patients with a diagnosis of AD and onset of disease for at least 1 year \* Moderate to severe AD Key Exclusion Criteria of the master protocol: \* Participants with a clinically significant medical condition or infectious disease (specified in sub-protocol) \* Participants with clinically significant abnormal hematology, clinical chemistry, or urine test results or clinically significant abnormal ECG \* Participant with any other active inflammatory skin disease \* Participants with any chronic, uncontrolled medical condition, which would put the 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