Study Description
This is a prospective, open label, single-arm, multicenter, non-interventional study of dabrafenib in combination with trametinib as adjuvant treatment for Chinese patients with stage III BRAF V600 mutation positive melanoma after complete resection.
Interventions
dabrafenib
trametinib
Eligibility Criteria
Inclusion Criteria:
Patient(s) must meet all of the following criteria to be eligible for inclusion:
≥18 years old of age at the time of informed consent and of Chinese descent
Signed written informed consent
Going to receive commercial dabrafenib and trametinib according to approved label
Completely resected histologically confirmed Stage III BRAF V600 mutation positive cutaneous or mucosal melanoma as defined by the following staging systems:
for stage III cutaneous melanoma: as per American Joint Committee on Cancer (AJCC) 8th edition for melanoma
for stage III mucosal melanoma of the head and neck origin: as per AJCC 8th edition for mucosal melanoma of the head and neck
for stage III mucosal melanoma of anal canal, rectum and genital track origin: as per Chinese guidelines on the diagnosis and treatment of melanoma 2019 edition
Must be surgically rendered free of disease (defined as the date of the most recent surgery) no more than 12 weeks before enrollment
Recovered from definitive surgery (e.g. no uncontrolled wound infections or indwelling drains)
Eastern Cooperative Oncology Group (ECOG) Performance Status of 0-1
Exclusion Criteria:
Patient will be excluded from this study if he/she meets any of the following criteria:
Known ocular melanoma
Patient received other systemic neo-adjuvant and/or adjuvant therapy for melanoma (including dabrafenib in combination with trametinib started before ICF signature)
Patient is not able to comply with the planned study procedures
Taken an investigational drug within 28 days prior to enrolment
History of another malignancy (including melanoma) or a concurrent malignancy, except malignancies that were treated curatively and have not recurred within 2 years prior to treatment.
Study Location
Novartis Investigative Site
Recruiting
Fuzhou,Fujian,350013,China
Novartis Investigative Site
Recruiting
Hangzhou,Zhejiang,310022,China
Novartis Investigative Site
Recruiting
Kunming,Yunnan,650106,China
Novartis Investigative Site
Recruiting
Nanjing,Jiangsu,210008,China
Novartis Investigative Site
Recruiting
Beijing,100036,China
Novartis Investigative Site
Recruiting
Wuhan,430022,China
Novartis Investigative Site
Recruiting
Changchun,Jilin,130022,China
Novartis Investigative Site
Recruiting
Zhengzhou,Henan,410100,China
Novartis Investigative Site
Recruiting
Changsha,Hunan,410013,China
Worldwide Contacts
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