Prospective ARNI vs ACE Inhibitor Trial to DetermIne Superiority in Reducing Heart Failure Events After MI

A Multi-center, Randomized, Double-blind, Active-controlled, Parallel-group Phase 3 Study to Evaluate the Efficacy and Safety of LCZ696 Compared to Ramipril on Morbidity and Mortality in High Risk Patients Following an AMI

ClinicalTrials.gov Identifier: NCT02924727

Novartis Reference Number: CLCZ696G2301

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All compounds are either investigational or being studied for (a) new use(s). Efficacy and safety have not been established. There is no guarantee that they will become commercially available for the use(s) under investigation. 

Study Description

The purpose of this study is to evaluate the efficacy and safety of LCZ696 titrated to a target dose of 200 mg twice daily, compared to ramipril titrated to a target dose of 5 mg twice daily, in addition to conventional post-AMI treatment, in reducing the occurrence of composite endpoint of CV death, HF hospitalization and outpatient HF (time-to-first event analysis) in post-AMI patients with evidence of LV systolic dysfunction and/or pulmonary congestion, with no known prior history of chronic HF..

Condition 
Acute Myocardial Infarction
Phase 
Phase 3
Overall status 
Active, not recruiting
Enrollment count 
5669 participants
Start date 
Dec 09, 2016
Completion date 
May 17, 2021
Gender 
All
Age(s)
18 Years and older (Adult, Older Adult)

Interventions

Drug
LCZ696 (sacubitril/valsartan)
LCZ696 (sacubitril/valsartan) tablet will be available in 24/26 mg, 49/51 mg and 97/103 mg, respectively
Drug
Ramipril
Ramipril 1.25 mg, 2.5 mg, and 5 mg oral capsules
Drug
Placebo of LCZ696
Matching placebo of LCZ696 tablets
Drug
Placebo of ramipril
Matching placebo of ramipril capsule
Drug
Valsartan
Valsartan (VAL489) 40 mg and 80 mg tablets, two doses for 1 day to patients who were previously treated with ACE inhibitors receiving the last dose of that agent during the last 36 hours prior to randomization
Drug
Placebo of valsartan
matching placebo of valsartan for one day to patients who will be randomized to received ramipril

Eligibility Criteria

Inclusion Criteria:

Male or female patients ≥ 18 years of age.
Diagnosis of spontaneous AMI based on the universal MI definition* with randomization to occur between 12 hours and 7 days after index event presentation. (*patients with spontaneous MI event determined to be secondary to another medical condition such as anemia, hypotension, or arrhythmia OR thought to be caused by coronary vasospasm with document normal coronary arteries are not eligible; patients with clinical presentation thought to be related to Takotsubo cardiomyopathy are also not eligible)

Evidence of LV systolic dysfunction and/or pulmonary congestion requiring intravenous treatment associated with the index MI event defined as:

LVEF ≤40% after index MI presentation and prior to randomization and/or
Pulmonary congestion requiring intravenous treatment with diuretics, vasodilators, vasopressors and/or inotropes, during the index hospitalization

At least one of the following 8 risk factors:

Age ≥ 70 years
eGFR <60 mL/min/1.73 m^2 based on MDRD formula at screening visit
Type I or II diabetes mellitus
Documented history of prior MI
Atrial fibrillation as noted by ECG, associated with index MI
LVEF <30% associated with index MI
Worst Killip class III or IV associated with index MI requiring intravenous treatment
STEMI without reperfusion therapy within the first 24 hours after presentation

Hemodynamically stable defined as:

SBP ≥ 100 mmHg at randomization for patients who received ACEi/ARB during the last 24 hours prior to randomization
SBP ≥ 110 mmHg at randomization for patients who did not receive ACEi/ARB during the last 24 hours prior to randomization
No IV treatment with diuretics, vasodilators, vasopressors and/or inotropes during the 24 hours prior to randomization

Key Exclusion Criteria:

Known history of chronic HF prior to randomization
Cardiogenic shock within the last 24 hours prior to randomization
Persistent clinical HF at the time of randomization
Coronary artery bypass graft (CABG) performed or planned for index MI
Clinically significant right ventricular MI as index MI
Symptomatic hypotension at screening or randomization
Patients with a known history of angioedema
Stroke or transient ischemic attack within one month prior to randomization
Known or suspected bilateral renal artery stenosis
Clinically significant obstructive cardiomyopathy
Open-heart surgery performed within one month prior to randomization or planned cardiac surgery w/in the 3 months prior to randomization
eGFR < 30 ml/min/1.73 m^2 as measured by MDRD at screening
Serum potassium > 5.2 mmol /L (or equivalent plasma potassium value) at randomization
Known hepatic impairment (as evidenced by total bilirubin > 3.0 mg/dL or increased ammonia levels, if performed), or history of cirrhosis with evidence of portal hypertension such as esophageal varices
Previous use of LCZ696
History of malignancy of any organ system (other than localized basal cell carcinoma of the skin) within the past 3 years with a life expectancy of less than 1year.
History of hypersensitivity to the study drugs or drugs of similar chemical classes or known intolerance or contraindications to study drugs or drugs of similar chemical classes including ACE inhibitors, ARB or NEP inhibitors
Pregnant or nursing women or women of child-bearing potential unless they are using highly effective methods of contraception

Study Locations

United States
Novartis Investigative Site
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Birmingham, 35243
Alabama
United States
Novartis Investigative Site
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Birmingham, 35294-2041
Alabama
United States
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Huntsville, 35801
Alabama
United States
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Gilbert, 85297
Arizona
United States
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Bakersfield, 93301
California
United States
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Carmichael, 95608
California
United States
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Los Alamitos, 90720
California
United States
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Northridge, 91325
California
United States
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Orange, 92868
California
United States
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San Francisco, 94143
California
United States
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Sylmar, 91342
California
United States
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Brandon, 33511
Florida
United States
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Hollywood, 33312
Florida
United States
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Jacksonville Beach, 32050
Florida
United States
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Ocala, 34480
Florida
United States
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Cumming, 30041
Georgia
United States
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Johns Creek, 30024
Georgia
United States
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Thomasville, 31792
Georgia
United States
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Boise, 83702
Idaho
United States
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Coeur d'Alene, 83814
Idaho
United States
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Muncie, 47303-3400
Indiana
United States
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Munster, 46321
Indiana
United States
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Richmond, 47374
Indiana
United States
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Iowa City, 52242
Iowa
United States
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Alexandria, 71301
Louisiana
United States
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Baton Rouge, 70808
Louisiana
United States
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Covington, 70433
Louisiana
United States
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Hammond, 70403
Louisiana
United States
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Slidell, 70458
Louisiana
United States
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Bangor, 04401
Maine
United States
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Baltimore, 21201
Maryland
United States
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Baltimore, 21218
Maryland
United States
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Rockville, 20850
Maryland
United States
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Springfield, 01104
Massachusetts
United States
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Detroit, 48201
Michigan
United States
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Kalamazoo, 49008
Michigan
United States
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Lansing, 48912
Michigan
United States
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Petoskey, 49770
Michigan
United States
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Saginaw, 48601
Michigan
United States
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Southfield, 48075
Michigan
United States
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Duluth, 55805
Minnesota
United States
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Robbinsdale, 55422
Minnesota
United States
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Saint Cloud, 56303
Minnesota
United States
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Saint Paul, 55101
Minnesota
United States
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Hattiesburg, 39401
Mississippi
United States
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Jackson, 39216
Mississippi
United States
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Kansas City, 64116
Missouri
United States
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Lee's Summit, 64064
Missouri
United States
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Lincoln, 68506
Nebraska
United States
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Lincoln, 68526
Nebraska
United States
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Omaha, 68114
Nebraska
United States
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Lebanon, 03756
New Hampshire
United States
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Hackensack, 07601
New Jersey
United States
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Flushing, 11355
New York
United States
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New York, 10016
New York
United States
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New York, 10029
New York
United States
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Valhalla, 10595
New York
United States
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Chapel Hill, 27599
North Carolina
United States
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Charlotte, 28204
North Carolina
United States
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Durham, 27710
North Carolina
United States
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Grand Forks, 58201
North Dakota
United States
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Canton, 44710
Ohio
United States
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Cincinnati, 45220
Ohio
United States
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Medford, 97504
Oregon
United States
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Erie, 16550
Pennsylvania
United States
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Hershey, 17033
Pennsylvania
United States
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York, 17403
Pennsylvania
United States
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Charleston, 29403
South Carolina
United States
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Columbia, 29203
South Carolina
United States
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Greenville, 29607
South Carolina
United States
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Rapid City, 57701
South Dakota
United States
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Knoxville, 37917
Tennessee
United States
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Nashville, 37212
Tennessee
United States
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Dallas, 75226
Texas
United States
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Houston, 77030
Texas
United States
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Webster, 77598
Texas
United States
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Danville, 24541
Virginia
United States
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Falls Church, 22042
Virginia
United States
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Lynchburg, 24501
Virginia
United States
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Manassas, 20109
Virginia
United States
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Bellevue, 98004
Washington
United States
Argentina
Novartis Investigative Site
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Caba, C1280AEB
Buenos Aires
Argentina
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La Plata, B1900AWT
Buenos Aires
Argentina
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Buenos Aires, C1078AAI
Caba
Argentina
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Ciudad de Salta, A4406BPF
Provincia De Salta
Argentina
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Tucuman, T4000ICL
San Miguel De Tucuman
Argentina
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Rosario, C2000DSR
Santa Fe
Argentina
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Rosario, S2000DSV
Santa Fe
Argentina
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San Miguel de Tucuman, T4000IFL
Tucuman
Argentina
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Buenos Aires, B1602ABQ
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Argentina
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Buenos Aires, B1846BMF
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Argentina
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Buenos Aires, C1405CNF
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Argentina
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Buenos Aires, C1428DCO
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Argentina
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Buenos Aires, C1430EGF
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Argentina
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Cordoba, X5000
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Argentina
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Cordoba, X5003DCP
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Argentina
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Cordoba, X5004BAL
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Argentina
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Cordoba, X5006CBI
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Argentina
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Corrientes, W3400
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Argentina
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Formosa, P3600
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Argentina
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San Luis, D5702JRS
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Argentina
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Santa Fe, S3000FUJ
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Argentina
Australia
Novartis Investigative Site
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Chemside, 4032
Queensland
Australia
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Herston, 4029
Queensland
Australia
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Bedford Park, 5041
South Australia
Australia
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Hobart, 7000
Tasmania
Australia
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Geelong, 3220
Victoria
Australia
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Murdoch, 6150
Western Australia
Australia
Austria
Novartis Investigative Site
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Innsbruck, 6020
Tyrol
Austria
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Braunau, A5280
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Austria
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Graz, 8036
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Austria
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Linz, A-4010
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Austria
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Salzburg, 5020
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Austria
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St Poelten, 3100
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Austria
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Wien, 1210
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Austria
Belgium
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Aalst, 9300
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Belgium
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Brasschaat, 2930
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Belgium
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Edegem, 2650
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Belgium
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Genk, 3600
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Belgium
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Leuven, 3000
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Belgium
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Turnhout, 2300
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Belgium
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Yvoir, 5530
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Belgium
Brazil
Novartis Investigative Site
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Fortaleza, 60430 370
CE
Brazil
Novartis Investigative Site
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Goiania, 74605 050
GO
Brazil
Novartis Investigative Site
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Belo Horizonte, 30140 062
MG
Brazil
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Uberlandia, 38411 186
Minas Gerais
Brazil
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Curitiba, 80730 150
Parana
Brazil
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Porto Alegre, 90620 001
RS
Brazil
Novartis Investigative Site
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Porto Alegre, 91350 200
RS
Brazil
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Blumenau, 89010 500
SC
Brazil
Novartis Investigative Site
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Campinas, 13060 080
SP
Brazil
Novartis Investigative Site
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Sao Jose do Rio Preto, 15090 000
SP
Brazil
Novartis Investigative Site
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Sao Paulo, 05403 000
SP
Brazil
Novartis Investigative Site
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Campina Grande do Sul, 83430 000
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Brazil
Novartis Investigative Site
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Sao Jose, 8001
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Brazil
Bulgaria
Novartis Investigative Site
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Burgas, 8018
BGR
Bulgaria
Novartis Investigative Site
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Sofia, 1407
BGR
Bulgaria
Novartis Investigative Site
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Blagoevgrad, 2700
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Bulgaria
Novartis Investigative Site
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Burgas, 8127
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Bulgaria
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Gabrovo, 5300
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Bulgaria
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Kardzhali, 6600
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Bulgaria
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Pernik, 2300
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Bulgaria
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Pleven, 5800
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Bulgaria
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Plovdiv, 4002
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Bulgaria
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Ruse, 7000
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Bulgaria
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Sofia, 1202
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Bulgaria
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Sofia, 1233
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Bulgaria
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Sofia, 1431
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Bulgaria
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Sofia, 1527
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Bulgaria
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Sofia, 1606
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Bulgaria
Novartis Investigative Site
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Sofia, 1709
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Bulgaria
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Varna, 9010
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Bulgaria
Canada
Novartis Investigative Site
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Edmonton, T6G 2E1
Alberta
Canada
Novartis Investigative Site
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Victoria, V8R4R2
British Columbia
Canada
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Ottawa, K1Y 4W7
Ontario
Canada
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Toronto, M5B 1W8
Ontario
Canada
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Montreal, H1T 1C8
Quebec
Canada
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Sainte Foy, G1V 4G5
Quebec
Canada
Novartis Investigative Site
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Terrebonne, J6V 2H2
Quebec
Canada
Novartis Investigative Site
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Trois Rivieres, G8Z 3R9
Quebec
Canada
China
Novartis Investigative Site
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Beijing, 100037
Beijing
China
Novartis Investigative Site
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Xicheng, 100044
Beijing
China
Novartis Investigative Site
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Lanzhou,
Gansu
China
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Guangzhou, 51000
Guangdong
China
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Guangzhou, 510080
Guangdong
China
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Shijiazhuang, 050000
Hebei
China
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Harbin, 150000
Heilongjiang
China
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Wuhan, 430060
Hubei
China
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Changsha, 410011
Hunan
China
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Nanjing, 210008
Jiangsu
China
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Nanjing, 210029
Jiangsu
China
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Chang Chun, 130021
Jilin
China
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Yanji,
Jilin
China
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Shengyang, 110016
Liaoning
China
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Jinan, 250013
Shandong
China
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Jinshan, 201508
Shanghai
China
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Shanghai, 200120
Shanghai
China
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Xian, 710061
Shanxi
China
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Tianjin, 300121
Tianjin
China
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Wenzhou, 325000
Zhejiang
China
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Beijing, 100029
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China
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Beijing, 100050
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China
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Beijing, 100191
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China
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Shanghai, 200080
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China
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Tianjin, 300052
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China
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Wuhan, 430022
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China
Colombia
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Medellin, 050001
Antioquia
Colombia
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Medellin,
Antioquia
Colombia
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Bucaramanga,
Santander
Colombia
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Cali, 760001
Valle Del Cauca
Colombia
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Barranquilla,
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Colombia
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Bogota,
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Colombia
Croatia
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Zagreb, 10000
HRV
Croatia
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Cakovec, 40000
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Croatia
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Zagreb, 10000
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Croatia
Czechia
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Kladno, 272 00
Czech Republic
Czechia
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Liberec, 46063
Czech Republic
Czechia
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Zlin, 762 75
Czech Republic
Czechia
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Brno Bohunice, 625 00
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Czechia
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Plzen-Bory, 305 99
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Czechia
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Prague 4, 146 24
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Czechia
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Praha 10, 100 34
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Czechia
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Praha, 12808
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Czechia
Denmark
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Aalborg, DK 9000
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Denmark
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Glostrup, 2600
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Denmark
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Herlev, 2730
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Denmark
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Hvidovre, 2650
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Denmark
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Svendborg, 5700
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Denmark
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Vejle, 7100
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Denmark
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Viborg, DK-8800
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Denmark
Finland
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Jyvaskyla, 40620
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Finland
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Kaupio, 70210
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Finland
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Tampere, 33520
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Finland
France
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Bron, 69677
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France
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Chambray les Tours, 37170
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France
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Corbeil Essonnes, 91100
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France
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Grenoble Cedex 9, 38043
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France
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Marseille Cedex 8, 13008
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France
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Paris cedex 18, 75877
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France
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Paris, 75010
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France
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Paris, 75015
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France
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Pessac Cedex, 33604
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France
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Toulouse Cedex, 31059
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France
Germany
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Augsburg, 86179
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Germany
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Bad Krozingen, 79189
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Germany
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Berlin, 13353
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Germany
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Bremen, 28277
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Germany
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Coburg, 96450
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Germany
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Dresden, 01307
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Germany
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Erfurt, 99089
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Germany
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Essen, 45122
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Germany
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Esslingen, 73730
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Germany
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Frankfurt, 60590
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Germany
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Frankfurt, 65929
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Germany
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Freiburg, 79106
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Germany
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Greifswald, 17475
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Germany
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Guetersloh, 33332
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Germany
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Hennigsdorf, 16761
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Germany
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Kiel, 24105
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Germany
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Koeln-Nippes, 50733
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Germany
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Koeln, 50937
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Germany
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Langen, 63225
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Germany
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Leverkusen, 51375
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Germany
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Ludwigshafen, 67063
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Germany
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Moenchengladbach, 41063
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Germany
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Neuss, 41464
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Germany
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Neuwied, 56564
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Germany
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Riesa, 01589
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Germany
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Ruesselsheim, 65428
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Germany
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Stadtlohn, 48703
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Germany
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Vechta, 49377
-
Germany
Novartis Investigative Site
-
Villingen-Schwenningen, 78052
-
Germany
Novartis Investigative Site
-
Witten, 58455
-
Germany
Novartis Investigative Site
-
Wuerzburg, 97080
-
Germany
Greece
Novartis Investigative Site
-
Alexandroupolis, 681 00
Evros
Greece
Novartis Investigative Site
-
Athens, 115 27
GR
Greece
Novartis Investigative Site
-
Athens, 14233
GR
Greece
Novartis Investigative Site
-
Larissa, 411 10
GR
Greece
Novartis Investigative Site
-
Athens, 115 21
-
Greece
Novartis Investigative Site
-
Athens, 115 27
-
Greece
Novartis Investigative Site
-
Athens, 115 28
-
Greece
Novartis Investigative Site
-
Athens, 12462
-
Greece
Hungary
Novartis Investigative Site
-
Pecs, 7621
Baranya
Hungary
Novartis Investigative Site
-
Zalaegerszeg, 8900
Zala
Hungary
Novartis Investigative Site
-
Budapest, 1027
-
Hungary
Novartis Investigative Site
-
Budapest, 1085
-
Hungary
Novartis Investigative Site
-
Budapest, 1134
-
Hungary
Novartis Investigative Site
-
Budapest, H 1096
-
Hungary
Novartis Investigative Site
-
Debrecen, 4032
-
Hungary
Novartis Investigative Site
-
Szeged, 6725
-
Hungary
Novartis Investigative Site
-
Szekesfehervar, H-8000
-
Hungary
India
Novartis Investigative Site
-
New Delhi, 110 060
Delhi
India
Novartis Investigative Site
-
New Delhi, 110007
Delhi
India
Novartis Investigative Site
-
Ahmedabad, 380 060
Gujarat
India
Novartis Investigative Site
-
Vadodara, 390022
Gujarat
India
Novartis Investigative Site
-
Karamsad, 388325
Gujrat
India
Novartis Investigative Site
-
Gurgaon, 122001
Haryana
India
Novartis Investigative Site
-
Kochi, 682 018
Kerala
India
Novartis Investigative Site
-
Mumbai, 400012
Maharashtra
India
Novartis Investigative Site
-
Nagpur, 440009
Maharashtra
India
Novartis Investigative Site
-
Nashik, 422005
Maharashtra
India
Novartis Investigative Site
-
Pune, 411001
Maharashtra
India
Novartis Investigative Site
-
Bikaner, 334003
Rajasthan
India
Novartis Investigative Site
-
Madurai, 625107
Tamil NADU
India
Novartis Investigative Site
-
Hyderabad, 500082
Telangana
India
Novartis Investigative Site
-
Secunderabad, 500003
Telangana
India
Novartis Investigative Site
-
DehraDun, 248001
Uttarakhand
India
Israel
Novartis Investigative Site
-
Ashkelon, 78278
-
Israel
Novartis Investigative Site
-
Haifa, 3525408
-
Israel
Novartis Investigative Site
-
Lower Galilee, 15208
-
Israel
Novartis Investigative Site
-
Petach Tikva, 49100
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Israel
Novartis Investigative Site
-
Sefad, 13100
-
Israel
Novartis Investigative Site
-
Tel Aviv, 6423906
-
Israel
Italy
Novartis Investigative Site
-
Bergamo, 24127
BG
Italy
Novartis Investigative Site
-
Bologna, 40133
BO
Italy
Novartis Investigative Site
-
Brescia, 25123
BS
Italy
Novartis Investigative Site
-
Catanzaro, 88100
CZ
Italy
Novartis Investigative Site
-
Cona, 44121
FE
Italy
Novartis Investigative Site
-
Sanremo, 18038
IM
Italy
Novartis Investigative Site
-
Milano, 20138
MI
Italy
Novartis Investigative Site
-
Milano, 20142
MI
Italy
Novartis Investigative Site
-
Milano, 20162
MI
Italy
Novartis Investigative Site
-
Roma, 00161
RM
Italy
Novartis Investigative Site
-
Roma, 00184
RM
Italy
Novartis Investigative Site
-
Rimini, 47900
RN
Italy
Novartis Investigative Site
-
Trieste, 34149
TS
Italy
Novartis Investigative Site
-
Grosseto, 58100
-
Italy
Novartis Investigative Site
-
Napoli, 80131
-
Italy
Novartis Investigative Site
-
Pavia, 27100
-
Italy
Korea, Republic of
Novartis Investigative Site
-
Cheongju si, 28644
Chungcheongbuk Do
Korea, Republic of
Novartis Investigative Site
-
Wonju, 26427
Gangwon-do
Korea, Republic of
Novartis Investigative Site
-
Gwangju, 61469
-
Korea, Republic of
Novartis Investigative Site
-
Seoul, 02841
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Korea, Republic of
Mexico
Novartis Investigative Site
-
Torreon, 27000
Coahulia
Mexico
Novartis Investigative Site
-
Culiacan Sinaloa, 08200
Distrito Federal
Mexico
Novartis Investigative Site
-
Guadalajara, 44670
Jalisco
Mexico
Novartis Investigative Site
-
Guadalajara, 45116
Jalisco
Mexico
Novartis Investigative Site
-
Ciudad de Mexico, 02980
-
Mexico
Novartis Investigative Site
-
Queretaro, 76000
-
Mexico
Novartis Investigative Site
-
San Luis Potosi, 78240
-
Mexico
Netherlands
Novartis Investigative Site
-
Sneek, 8601 ZR
The Netherlands
Netherlands
Novartis Investigative Site
-
Alkmaar, 1815 JD
-
Netherlands
Novartis Investigative Site
-
Almelo, 7609 PP
-
Netherlands
Novartis Investigative Site
-
Amersfoort, 3813 TZ
-
Netherlands
Novartis Investigative Site
-
Amsterdam, 1091AC
-
Netherlands
Novartis Investigative Site
-
Beverwijk, NL-1942 LE
-
Netherlands
Novartis Investigative Site
-
Breda, 4818 CK
-
Netherlands
Novartis Investigative Site
-
Ede, 6716 RP
-
Netherlands
Novartis Investigative Site
-
Gouda, 2803 HH
-
Netherlands
Novartis Investigative Site
-
Groningen, 9713 GZ
-
Netherlands
Novartis Investigative Site
-
Heemstede, 2102 CW
-
Netherlands
Novartis Investigative Site
-
Leeuwarden, 8934 AD
-
Netherlands
Novartis Investigative Site
-
Leiderdorp, 2353 GA
-
Netherlands
Novartis Investigative Site
-
Rotterdam, 3015 CE
-
Netherlands
Novartis Investigative Site
-
Rotterdam, 3045 PM
-
Netherlands
Novartis Investigative Site
-
Rotterdam, 3083 AN
-
Netherlands
Novartis Investigative Site
-
Tilburg, 5042 AD
-
Netherlands
Novartis Investigative Site
-
Uden, 5406 PT
-
Netherlands
Novartis Investigative Site
-
Veldhoven, 5504 DB
-
Netherlands
Novartis Investigative Site
-
Venlo, 5912 BL
-
Netherlands
Novartis Investigative Site
-
Zutphen, 7207 AE
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Netherlands
Novartis Investigative Site
-
Zwolle, 8025 AB
-
Netherlands
Norway
Novartis Investigative Site
-
Gralum, 1714
-
Norway
Novartis Investigative Site
-
Oslo, 0372
-
Norway
Novartis Investigative Site
-
Stavanger, 4068
-
Norway
Peru
Novartis Investigative Site
-
Bellavista, CALLAO 02
Lima
Peru
Novartis Investigative Site
-
Cercado De Lima, 01
Lima
Peru
Novartis Investigative Site
-
Jesus Maria, 11
Lima
Peru
Novartis Investigative Site
-
Lima, 10
-
Peru
Philippines
Novartis Investigative Site
-
Iloilo city, 5000
Iloilo
Philippines
Novartis Investigative Site
-
Quezon City, 1100
Manila
Philippines
Novartis Investigative Site
-
Manila, 1000
Metro Manila
Philippines
Poland
Novartis Investigative Site
-
Bialystok, 15 276
-
Poland
Novartis Investigative Site
-
Lubin, 59-301
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Poland
Novartis Investigative Site
-
Lublin, 20-718
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Poland
Novartis Investigative Site
-
Warszawa, 02-097
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Poland
Novartis Investigative Site
-
Warszawa, 02-507
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Poland
Portugal
Novartis Investigative Site
-
Carnaxide, 2799 523
Lisboa
Portugal
Novartis Investigative Site
-
Almada, 2801 951
-
Portugal
Novartis Investigative Site
-
Braga, 4710243
-
Portugal
Novartis Investigative Site
-
Coimbra, 3041-853
-
Portugal
Novartis Investigative Site
-
Covilha, 6200-251
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Portugal
Novartis Investigative Site
-
Faro, 8000 386
-
Portugal
Novartis Investigative Site
-
Guimaraes, 4835 044
-
Portugal
Novartis Investigative Site
-
Leiria, 2410-187
-
Portugal
Novartis Investigative Site
-
Lisboa, 1649-035
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Portugal
Novartis Investigative Site
-
Vila Real, 5000-508
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Portugal
Romania
Novartis Investigative Site
-
Pitesti, 110438
Arges
Romania
Novartis Investigative Site
-
Bucuresti, 4204179
District 4
Romania
Novartis Investigative Site
-
Oradea, 410169
Jud Bihor
Romania
Novartis Investigative Site
-
Cluj Napoca, 400001
Jud Cluj
Romania
Novartis Investigative Site
-
Iasi, 700732
Jud Iasi
Romania
Novartis Investigative Site
-
Targu Mures, 540124
Mures
Romania
Novartis Investigative Site
-
Braila, 810249
ROM
Romania
Novartis Investigative Site
-
Suceava, 727525
ROM
Romania
Novartis Investigative Site
-
Timisoara, 300362
Timis
Romania
Novartis Investigative Site
-
Baia Mare, 430031
-
Romania
Novartis Investigative Site
-
Bucharest, 022322
-
Romania
Novartis Investigative Site
-
Bucharest, 041915
-
Romania
Novartis Investigative Site
-
Bucharest, 050098
-
Romania
Novartis Investigative Site
-
Bucuresti, 011461
-
Romania
Novartis Investigative Site
-
Bucuresti,
-
Romania
Novartis Investigative Site
-
Craiova, 200642
-
Romania
Novartis Investigative Site
-
Sibiu, 550245
-
Romania
Novartis Investigative Site
-
Timisoara, 300041
-
Romania
Novartis Investigative Site
-
Timisoara, 300310
-
Romania
Russian Federation
Novartis Investigative Site
-
Barnaul, 656038
-
Russian Federation
Novartis Investigative Site
-
Kemerovo, 650002
-
Russian Federation
Novartis Investigative Site
-
Krasnodar, 350086
-
Russian Federation
Novartis Investigative Site
-
Moscow, 115516
-
Russian Federation
Novartis Investigative Site
-
Moscow, 117292
-
Russian Federation
Novartis Investigative Site
-
Moscow, 121359
-
Russian Federation
Novartis Investigative Site
-
Moscow, 121552
-
Russian Federation
Novartis Investigative Site
-
Moscow, 127644
-
Russian Federation
Novartis Investigative Site
-
Murmansk, 183047
-
Russian Federation
Novartis Investigative Site
-
N.Novgorod, 603005
-
Russian Federation
Novartis Investigative Site
-
Nizhnii Novgorod, 603126
-
Russian Federation
Novartis Investigative Site
-
Rostov on Don, 344068
-
Russian Federation
Novartis Investigative Site
-
S.-Petersburg, 192242
-
Russian Federation
Novartis Investigative Site
-
Saint Petersburg, 197341
-
Russian Federation
Novartis Investigative Site
-
Saint-Petersburg, 194044
-
Russian Federation
Novartis Investigative Site
-
Saratov, 410012
-
Russian Federation
Novartis Investigative Site
-
Sestroretsk, 197706
-
Russian Federation
Novartis Investigative Site
-
Sochy, 354057
-
Russian Federation
Novartis Investigative Site
-
St Petersburg, 191014
-
Russian Federation
Novartis Investigative Site
-
St Petersburg, 191015
-
Russian Federation
Novartis Investigative Site
-
St Petersburg, 194291
-
Russian Federation
Novartis Investigative Site
-
Tomsk, 634012
-
Russian Federation
Novartis Investigative Site
-
Yekaterinburg, 620109
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Russian Federation
Singapore
Novartis Investigative Site
-
Singapore, 119074
-
Singapore
Novartis Investigative Site
-
Singapore, 169609
-
Singapore
Novartis Investigative Site
-
Singapore, 308433
-
Singapore
Novartis Investigative Site
-
Singapore, 529889
-
Singapore
Novartis Investigative Site
-
Singapore, 768828
-
Singapore
Slovakia
Novartis Investigative Site
-
Bratislava, 826 06
Slovak Republic
Slovakia
Novartis Investigative Site
-
Nitra, 949 01
Slovak Republic
Slovakia
Novartis Investigative Site
-
Banska Bystrica, 974 01
SVK
Slovakia
Novartis Investigative Site
-
Bratislava, 833 48
-
Slovakia
Novartis Investigative Site
-
Kosice, 040 11
-
Slovakia
Novartis Investigative Site
-
Presov, 081 81
-
Slovakia
South Africa
Novartis Investigative Site
-
Pinelands, 7405
Cape Town
South Africa
Novartis Investigative Site
-
Cape Town, 7500
Western Cape
South Africa
Novartis Investigative Site
-
George, 6529
Western Cape
South Africa
Novartis Investigative Site
-
Cape Town, 7925
-
South Africa
Novartis Investigative Site
-
Worcester, 6850
-
South Africa
Spain
Novartis Investigative Site
-
Malaga, 29010
Andalucia
Spain
Novartis Investigative Site
-
Sevilla, 41014
Andalucia
Spain
Novartis Investigative Site
-
Badalona, 08916
Barcelona
Spain
Novartis Investigative Site
-
Villamartin, 11650
Cadiz
Spain
Novartis Investigative Site
-
Leon, 24071
Castilla Y Leon
Spain
Novartis Investigative Site
-
Valencia, 46010
Comunidad Valenciana
Spain
Novartis Investigative Site
-
Caceres, 10003
Extremadura
Spain
Novartis Investigative Site
-
A Coruna, 15006
Galicia
Spain
Novartis Investigative Site
-
La Coruna, 15006
Galicia
Spain
Novartis Investigative Site
-
Barcelona, 08041
-
Spain
Novartis Investigative Site
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El Palmar (Murcia), 30120
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Spain
Novartis Investigative Site
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Madrid, 28041
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Spain
Novartis Investigative Site
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Valencia, 46026
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Spain
Sweden
Novartis Investigative Site
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Stockholm, 141 86
SE
Sweden
Novartis Investigative Site
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Goethenburg,
-
Sweden
Novartis Investigative Site
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Helsingborg, 252 20
-
Sweden
Novartis Investigative Site
-
Helsingborg, 25232
-
Sweden
Novartis Investigative Site
-
Malmo, 221 85
-
Sweden
Novartis Investigative Site
-
Stockholm, 118 83
-
Sweden
Novartis Investigative Site
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Uppsala, 751 85
-
Sweden
Novartis Investigative Site
-
Vasteras, 72189
-
Sweden
Switzerland
Novartis Investigative Site
-
Bern, 3010
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Switzerland
Novartis Investigative Site
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Lugano, 6903
-
Switzerland
Novartis Investigative Site
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Luzern 16, CH 6000
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Switzerland
Novartis Investigative Site
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St Gallen, 9007
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Switzerland
Taiwan
Novartis Investigative Site
-
New Taipei, 22060
-
Taiwan
Novartis Investigative Site
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Taichung, 40447
-
Taiwan
Novartis Investigative Site
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Tainan, 71004
-
Taiwan
Novartis Investigative Site
-
Taipei, 10002
-
Taiwan
Novartis Investigative Site
-
Taipei, 10449
-
Taiwan
Novartis Investigative Site
-
Taipei, 11217
-
Taiwan
Novartis Investigative Site
-
Taoyuan, 33305
-
Taiwan
Novartis Investigative Site
-
Yilan, 26058
-
Taiwan
Thailand
Novartis Investigative Site
-
Bangkok, 10330
THA
Thailand
Novartis Investigative Site
-
Khon Kaen, 40002
THA
Thailand
Novartis Investigative Site
-
Bangkok, 10700
-
Thailand
Novartis Investigative Site
-
Chiang Mai, 50200
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Thailand
Turkey
Novartis Investigative Site
-
Eskisehir, 26480
Meselik
Turkey
Novartis Investigative Site
-
Ankara-Cankaya, 06100
-
Turkey
Novartis Investigative Site
-
Istanbul, 34304
-
Turkey
Novartis Investigative Site
-
Istanbul, 34865
-
Turkey
Novartis Investigative Site
-
Izmir, 35040
-
Turkey
Novartis Investigative Site
-
Izmir, 35340
-
Turkey
Novartis Investigative Site
-
Kocaeli, 41380
-
Turkey
Novartis Investigative Site
-
Kucukcekmece/Istanbul, 34303
-
Turkey
Novartis Investigative Site
-
Mersin, 33343
-
Turkey
Novartis Investigative Site
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Sivas, 58140
-
Turkey
Novartis Investigative Site
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Trabzon, 61080
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Turkey
United Kingdom
Novartis Investigative Site
-
Basingstoke, RG24 9NA
Hampshire
United Kingdom
Novartis Investigative Site
-
Lincoln, LN2 5QY
Lincolnshire
United Kingdom
Novartis Investigative Site
-
Craigavon, BT63 5QQ
Northern Ireland
United Kingdom
Novartis Investigative Site
-
Clydebank, G81 4HX
West Dumbartonshire
United Kingdom
Novartis Investigative Site
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Belfast, BT12 6BA
-
United Kingdom
Novartis Investigative Site
-
Birmingham, B9 5SS
-
United Kingdom
Novartis Investigative Site
-
Bournemouth, BH7 7DW
-
United Kingdom
Novartis Investigative Site
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Glasgow, G51 4TF
-
United Kingdom
Novartis Investigative Site
-
Leeds, LS1 3EX
-
United Kingdom
Novartis Investigative Site
-
Leicester, LE3 9QP
-
United Kingdom
Novartis Investigative Site
-
Middlesborough, TS4 3BW
-
United Kingdom
Novartis Investigative Site
-
Newcastle upon Tyne, NE7 7DN
-
United Kingdom
Novartis Investigative Site
-
Norwich, NR4 7UY
-
United Kingdom
Novartis Investigative Site
-
Worcester, WR5 1DD
-
United Kingdom

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