Global Discovery Chemistry
Emeryville, California, United States
The focus of my efforts in the Structural and Biophysical Chemistry Group is early stage hit finding and hit validation for antiviral, antibacterial, and anticancer agents. We routinely employ biophysical methods (e.g., SPR, DSF, ITC) to enable project teams and to discover hits against key viral proteins by a variety of methods, including fragment-based screening and drug design, high-throughput screening, and the rational design of inhibitors. Our goal is to deliver well-validated molecules to the crystallographers to determine the structure of the molecule in the protein’s active site. We also perform mechanistic studies to probe protein-protein interactions that support hypotheses for a given anti-viral mechanism. We are constantly looking for novel technologies to gain unique insight into target-based drug discovery, and to improve our understanding of virology, with the ultimate goal of improving the lives of patients in need. Our current need is to expand our understanding of the biochemistry and cellular biology of BK virus (BKV), a polyomavirus, so that we can effectively stop the proliferation of the virus.
Molecular basis of mRNA cap recognition by Influenza B Polymerase PB2 subunit
Xie L, Wartchow C, Shia S, Uehara K, Steffek M, Warne R, Sutton J, Muiru GT, Leonard VH, Bussiere DE, Ma X.
J Biol Chem. 2016 Jan 1;291(1):363-70
Deconstruction of a nutlin: dissecting the binding determinants of a potent protein-protein interaction inhibitor
Fry DC, Wartchow C, Graves B, Janson C, Lukacs C, Kammlott U, Belunis C, Palme S, Klein C, Vu B.
ACS Med Chem Lett. 2013 May 24;4(7):660-5
Biosensor-based small molecule fragment screening with biolayer interferometry
Wartchow CA, Podlaski F, Li S, Rowan K, Zhang X, Mark D, Huang KS.
J Comput Aided Mol Des. 2011 Jul;25(7):669-76
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