Mar 22, 2023

Job Description

200+! This is the current number of programs in clinical development at Novartis. Many of these projects, which include new molecular entities as well as additional indications and different formulations for marketed products, are for medicines that could significantly advance treatment standards for patients worldwide.

As an experienced subject matter expert in the application of milling technologies for the preparation of drug substances and drug products, you will support a New Chemical Entities project portfolio, focusing on small molecules. As part of a Materials Science team, you will scientifically drive the development of laboratory processes and support the transfer of processes to pilot and commercial manufacturing facilities.
You will also play a key role in strengthening scientific excellence at the interface between drug substance and drug product development and will bring with you a deep understanding of both particle and powder properties, which you can apply to successfully support project teams operating in both early and late phase development.
In addition, you will work alongside crystallization and solid state experts as well as formulators to optimize the physical properties of a drug substance for subsequent use in drug product development.

Your key responsibilities will include:
Ensure the development of robust sieving and milling operation steps for integration into both the chemical and pharmaceutical manufacturing chains
Transfer of processes to and between pilot plants and commercial facilities, both internally and externally
Drive discussions relating to powder and particle properties as a subject matter expert, and support interpretation of appropriate analytical results
Drive cross-team and cross-functional knowledge exchange in the areas of milling and sieving and more broadly (particle science, powder properties) through coaching to increase the skill base relating to Materials Science
Be an advocate for strengthening the interface between drug substance and drug product development, both within the Materials Science unit and within Project Teams

Diversity & Inclusion / EEO

Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

Minimum Requirements

Ideal requirements:
• PhD in relevant scientific field (e.g. particle technology, (mechanical) process engineering, materials science)
• Minimum 3 years of successful pharma industry experience as a subject matter expert in milling (development and/or manufacturing setting, ideally both). Familiarity with HSE for powder processing and GMP requirements would be advantageous
• In-depth technical knowledge of appropriate process technologies used to achieve, in particular, particle size reduction during the manufacture of both drug substances and drug products. Specifically, dry operations such as sieving, milling, micronisation and wet operations such as wet-media milling.
• Profound knowledge in fundamental powder (and suspension) characterization technologies (e.g. laser light diffraction, ring shear tester, analytical centrifugation, dynamic vapor sorption, dynamic light scattering, zeta potential, etc.)
• Experience in the stage appropriate requirements in drug substance and drug product technical development from early to late stage development as well as process transfers to commercial facilities
• Strong communication, negotiation, presentation, technical writing, coaching skills. Desire to help associates grow in new and existing roles .
• Interdisciplinary thinking and strength in cross-functional collaboration
• Experience in working within complex stakeholder environments with extensive interfaces
• Excellent planning and work prioritization skills.
• English (fluent) required. German desirable.

Why Novartis?

769 million lives were touched by Novartis medicines in 2020, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.

We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!

Imagine what you could do here at Novartis!

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network
Global Drug Development
Research & Development
Full Time
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Scientific Expert (Milling Technologies & Powder Science - Ass. Dir)

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