Mar 20, 2023

Job Description

1 Purpose – to reimagine medicine! Come join the Novartis Institutes for Biomedical Research (NIBR) as a Discovery Postdoctoral Fellow and contribute to tackling one of the most pressing challenges in Oncology – tumor resistance.

NIBR is the innovation engine of Novartis. We collaborate across scientific and organizational boundaries, with a focus on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients.

Our Oncology Team in Cambridge, Massachusetts is seeking highly motivated and team-oriented Postdoctoral Fellows to form a Postdoctoral Hub that will focus on tumor plasticity and mechanisms of resistance to Ras/Raf/MAPK pathway therapies. The projects will combine multiple lines of investigation, including in vivo models, genetic screening, tumor microenvironment analysis, biochemical and cellular studies, molecular biology and transcriptomic profiling.

Candidates will join a vibrant scientific community and collaborate with experts across disciplines and platforms including data-science, translational oncology, and drug discovery. This is an outstanding opportunity to conduct innovative, interdisciplinary research expected to be published in leading journals. The postdoctoral term is up to 4 years and will be under direct mentorship of Drs. Shiva Malek, Vesselina Cooke, Carmine Fedele, Saskia Brachmann, Adelajda Hadzipasic and Erin Artin.

Specifically, we are seeking:

Two (2) postdoctoral fellows with good understanding of the mechanisms of oncogenic progression, signal transduction, and interplay between the tumor and its microenvironment, who are eager to learn new therapeutic approaches and/or combinatorial strategies using pre-clinical models.

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What You'll Bring to the Role:

* Ph.D., M.D./Ph.D. in Molecular or Cellular Biology or related subject area.
* Strong independent thinker, focused on discovery, problem solver, curious, great organizational skills and dedicated to performing research of the highest quality.
* Excellent record of academic achievements (e.g., publications, awards, fellowships etc.).
* Hands-on in vivo experience with mouse models and techniques (e.g., xenografts, GEMMs, syngeneic/orthotopic, general husbandry, survival surgery procedures, IP, IV, SC and oral gavage dosing) is necessary.
* Experience with standard molecular and cell biology techniques, such as qPCR, flow cytometry, immunoassays, cell line engineering and genetic perturbation techniques is necessary.
* Experience with functional genetic screening, transcriptomic profiling methods and data analysis would be an advantage, although training in these areas is available.
* Experience in working independently and across teams and fostering productive research collaborations.
* Excellent communication and presentation skills.

How to apply:

* Please submit a cover letter and CV
* One-page description of your research accomplishments to date
* Contact information for 2 references

For more information about our postdoctoral program, please visit: https://www.novartis.com/careers/postdoc-program

Why Novartis?

766 million lives were touched by Novartis medicines in 2021, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives. We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!

Imagine what you could do here at Novartis!

Commitment to Diversity & Inclusion

Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

Accessibility and Reasonable Accommodations

Individuals in need of a reasonable accommodation due to a medical condition or disability for any part of the application process, or to perform the essential functions of a position, please send an e-mail to [email protected] or call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

The pay rate for this position at commencement of employment is expected to be $70,000 per year; however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors. #PDX
Oncology NIBR
Cambridge, MA
Research & Development
Full Time
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Discovery Fellow, Mechanisms of Tumor Resistance (Pharmacology)

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