Oct 18, 2022

Job Description

6,000! That is the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients.

This role is for a Senior Scientist in the Analytics and Separations group within the Global Discovery Chemistry (GDC) department in Cambridge, MA. In partnership with research and discovery chemistry, the Separations Team confronts the ambitious task of developing analytical and preparative methods for the analysis and purification of achiral and chiral drug discovery molecules.

We are seeking a curious and creative scientist with experience in analytical chemistry and purification and an interest in lab automation systems. The successful candidate will be able to deliver efficient purification workflows using SFC, HPLC, and automated liquid handling platforms. An interest in scripting methods for complex workflows would be beneficial.

Your Key Responsibilities:

- Support medicinal chemistry projects across a variety of disease areas by developing purification workflows in a high throughput automated environment.

- Be a diligent, dedicated lab scientist who executes automated analytical method development and preparative purification workflows with subsequent fraction pooling using automated liquid handlers. Generate final reports including QC package with LCMS and NMR confirmation.

- Troubleshooting and maintenance of SFC ad HPLC instrumentation and laboratory robotics.

- Work with manager and colleagues to troubleshoot issues, iterate and optimize existing automation scripts and workflows.

- Identify and pursue new projects and technologies that directly impact throughput of purifications in early drug discovery research.

- Communicate clearly and work closely with analytical scientists, medicinal chemists, and scientists from a diverse range of disciplines within NIBR.

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you will bring to the role:

- A Bachelors or Masters in Chemistry, lab automation, or related field with at least 5 years of relevant industry experience purifying compounds in a drug discovery environment.

- Specific experience in operating SFC and HPLC analytical and preparative instrumentation.

- Strong technical skills troubleshooting analytical instrumentation and operating chromatography software (Masslynx, Chromscope, Chemstation, or similar).

- Proficient with automated liquid handling systems (Tecan, Sirius, or similar).

- Strong skills in data analysis, interpretation, management, and data science.

- Diligent and accurate working style, excellent communication and organization skills required.

Desirable requirements:

- Experience with optimization of laboratory workflows to increase efficiency and throughput.

- Basic organic chemistry knowledge.

- Additional programming skills (KNIME, Python, Visual Studio/C#, Java, or similar) is a plus.

Why Novartis?

766 million lives were touched by Novartis medicines in 2021, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.

We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!

Imagine what you could do here at Novartis!

Commitment to Diversity & Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

Accessibility and Reasonable Accommodations: Individuals in need of a reasonable accommodation due to a medical condition or disability for any part of the application process, or to perform the essential functions of a position, please send an e-mail to [email protected] or call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network
Global Discovery Chemistry
Cambridge, MA
Research & Development
Full Time
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Senior Scientist - Analytics, Purifications, and Automation

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