Sep 26, 2022

Job Description

300,000 babies globally, and 1 out of every 365 African American births in the US each year, are affected with sickle cell disease (SCD). The Engineered Therapeutic Group of Chemical Biology & Therapeutics (CBT) at Novartis Institutes for BioMedical Research (NIBR) in Cambridge, MA, has made key contributions to a novel CRISPR based gene therapy for SCD which is currently in Phase I clinical trials. We are seeking a highly motivated Principal Scientist to develop novel non-nuclease based in vivo gene editing technologies that are suitable for clinical development. Our team is embedded in the Genome Science Home of CBT which consists of more than 60 scientists across Basel, San Diego, and Cambridge, with diverse expertise from genome engineering, next gen sequencing, and high throughput genetic screens. The successful candidate will focus on developing methods for targeted insertion of a therapeutic cargo in vivo.

Your responsibilities include:

- Developing and optimizing methods for the insertion of multifaceted cargos into therapeutically relevant cells/tissues at clinically meaningful efficiency and scale.

- Conceiving novel project concepts, building and leading a cross-functional team for implementing the strategy. The role includes significant leading from the bench.

- Participating in due diligence teams to evaluate potential in-licensing or partnering opportunities as they arise.

- Communicating effectively with diverse project teams and presenting to departmental and institutional leaderships.

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you will bring to the role:

- PhD, or MS and equivalent experience, with genome engineering as the main focus of the thesis, and 3+ years of direct, hands-on experience with the engineering of genome modifying effectors especially transposons/transposases.

- Knowledge and experience (either direct or via collaboration) in phylogeny analysis of protein/enzyme families are highly valued.

- Demonstrated leadership and/or mentoring experience.

- Comfort in a collaborative, collegial, non-hierarchical, highly-dynamic matrixed environment.

- Excellent oral and written communication skills, including the ability to speak to audiences and partners at all levels, internally or externally.

Desirable Skills:

- Experiences with editing of human primary cells.

- Ability to exploit protein folding, engineering, or structure tools such as Alphafold, PDB, and PepBank.

Why Novartis?

766 million lives were touched by Novartis medicines in 2021, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.

We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!

Imagine what you could do here at Novartis!

Commitment to Diversity & Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

Accessibility and Reasonable Accommodations: Individuals in need of a reasonable accommodation due to a medical condition or disability for any part of the application process, or to perform the essential functions of a position, please send an e-mail to [email protected] or call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network
Cambridge, MA
Research & Development
Full Time
careers default image

Principal Scientist, Cell & Gene Therapy

Apply to Job Access Job Account