Sep 12, 2022

Job Description

Over 35 preclinical targets in our pipeline! NIBR Oncology strives to reimagine medicine for cancer patients through a combination of targeted immunotherapies including CAR-T, immune cell-engager, antibody drug conjugate and radioligand therapy. The Immune Cell Engager Biotherapeutics Group is committed to the discovery of robust first-in-class next generation antibodies for the treatment of solid and hematological cancers.

We are seeking a highly passionate and motivated research scientist to join our team at Novartis Oncology Biotherapeutics in Cambridge, MA. This position is ideal for someone who is creative, highly collaborative, result-oriented and wishes to combine their curiosity about oncology, cancer immunology and drug discovery to save patients’ lives. In this role, you will have the opportunities to contribute to exploratory and innovative biotherapeutic drug discovery for cancer using a variety of different assays to independently support research in this area. The successful candidate will become a crucial part of a dynamic and multidisciplinary group to interact with other functional groups and to understand the process of preclinical drug discovery, that will eventually transform the lives of cancer patients.

Your responsibilities include, but are not limited to:
- Design and perform experiments including in vitro assays to screen for immune cell engaging (ICE) antibodies or biologics

- Critically analyze and summarize data to support decision to progress project along the discovery pipeline

- Explore or interrogate current biology of emerging drug targets for validation

- Use automation and high-throughput system to support large scale ICE antibody screening

- Detailed documentation and organization of experimental results in electronic laboratory notebooks

- Present research updates clearly and effectively and participate in internal and external meetings

- Troubleshoot complex problems in creative ways and actively participate in optimization of established procedures to ensure delivery on team goals

This position will be located at the Cambridge, MA site and will not have the ability to be located remotely. This position will not require any travel as defined by the business (domestic and/ or international).”

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you’ll bring to the role:
- BS with 2-5 years of experience or a MS with 0-4 years of experience. Experience in academia or industry in cancer immunotherapy, cancer biology, molecular biology, antibody therapeutics or related field
- Basic knowledge in immuno-oncology, immunology or cell and molecular biology
- Extensive hands-on expertise with immune cell isolation and culture, in vitro cell assay (especially T cell and monocyte/macrophage assays), and molecular techniques including transient/stable cell line generation, ELISA/MSD, and RT-qPCR
- Experience with functional immune cell assay techniques, including proliferation assay, cytokine profiling and cytotoxicity assays
- Capable of documenting experiments, analyzing, and interpreting data, as well as presenting results within a multi-disciplinary team environment
- Excellent communication and team collaboration skills

Desirable Qualifications:
- Prior proven experience with antibodies or biologics drug discovery
- Experience with high-throughput instruments.
- Proficient at designing, executing, and analyzing multi-color flow cytometry assays for phenotypic characterization of mouse and human immune cell subsets
- Gene silencing, western blotting, and immunofluorescence

Why Novartis?

766 million lives were touched by Novartis medicines in 2021, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.

We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!

Imagine what you could do here at Novartis!

Commitment to Diversity & Inclusion:
Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

Accessibility and Reasonable Accommodations: Individuals in need of a reasonable accommodation due to a medical condition or disability for any part of the application process, or to perform the essential functions of a position, please send an e-mail to [email protected] or call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Vaccine Policy:
While Novartis does not require vaccination at this time, for certain Novartis sites in the US all associates and candidates may be required to either upload an image of their COVID-19 vaccine card demonstrating proof of full vaccination for COVID-19 (or other similar evidence of vaccination) or proof of a negative COVID-19 test taken by the associate or candidate within the past seven days to enter any of our sites and/or customer office or healthcare facility, as well as prior to participating in other work related off-site meetings. Employees working in customer-facing roles must adhere to and comply with customers’ (such as hospitals, physician offices, etc.) credentialing guidelines, which may require vaccination. As required by applicable law, Novartis will consider requests for reasonable accommodation for those unable to be vaccinated. This requirement is subject to applicable state and local laws and may not be applicable to employees working in certain jurisdictions. Please send accommodation requests to [email protected].

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https:
Oncology NIBR
Cambridge, MA
Research & Development
Full Time
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BS/MS Research Scientist, Oncology Drug Discovery - Biotherapeutics

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