349289BR
Aug 18, 2022
Switzerland

Job Description

6000+! That’s the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients.

We are seeking a highly motivated scientist with at least 3 years of experience in pre-clinical pharmaceutical development to join the Biotherapeutic Engineering and Gene Therapy (BEGT) group within NBC in Basel, Switzerland.

within NBC in Basel, Switzerland. The BEGT group drives a diverse portfolio of modalities including therapeutic proteins, multi-specific antibodies, CAR-T, RNA therapeutics and AAV. Through innovative and rational modality design, the BEGT group works collaboratively with Disease area groups to broaden the use of biologics into therapeutic applications where conventional antibodies have limitations. The ideal candidate will have a proven track record in evaluation of bio-conjugate therapeutics. Hands-on experience in cell culture, compound analytics and molecular biology techniques are a plus.

Your responsibilities will include:

• Closely work with bioconjugation scientists and provide support in binder-oligonucleotide construct validation including functional characterization RNA constructs via in vitro cellular assays for selectivity and activity.
• Investigate intracellular mechanisms of action of novel oligonucleotide binder conjugates.
• Establishing novel assays to support development of binder-oligonucleotide constructs and their components with emphasis on method development for quantification, construct validation and stability of constructs in different environments.
• Provide technical reports and documentation accurately and on time.
• Execute detailed protocols and techniques necessary for several molecular and cellular biology assays
• Source, maintain, and manipulate mammalian cells in culture
• Adapt protocols and techniques to high-throughput assays in 96- & 384-well plate-based formats
• Analyze data and interpret results into a professional, presentable format

Diversity & Inclusion / EEO

Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

Minimum Requirements

What you will bring to the role:

• Experience with culturing primary hepatic cells is a plus.
• Hands on experience and with antibody characterization is a plus.
• Hands on lab experience with cell culture, RNA isolation, real-time qRT-PCR, ELISA, western blot, immunohistochemistry and flow cytometry.
• Expertise in the cellular and functional characterization of oligonucleotides and prior experience with shRNA and AAV technologies are a plus.

• Experience in assay automation beneficial
Capability of running experiments independently
Demonstrated ability to troubleshoot instruments and analytical assays.
• Highly collaborative spirit in- and outside of department to advance programs to clinic, strong communication skills, creativity, and multi-tasking in a fast-paced environment

Desirable requirements:
• MS degree in pharmaceutical sciences, biochemistry, molecular or cell biology, or a related field, or a BS degree and 3 + years of relevant laboratory experience.

Why consider Novartis?

799 million. That’s how many lives our products touched in 2019. And while we’re proud of that fact, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people’s lives?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.

Imagine what you could do at Novartis!

*Some restrictions to flexible working may apply and will be discussed during interview as applicable.

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to learn more about Novartis and our career opportunities, join the Novartis Network here:
https://talentnetwork.novartis.com/network
NIBR
BIOLOGICS NIBR
Switzerland
Basel
Research & Development
Full Time
Regular
No
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349289BR

Senior Scientist I - Therapeutic RNA (80-100%*)

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