Jul 14, 2022

Job Description

$9.0 billion R&D spend to develop breakthrough medicines!

Cardiovascular disease is the leading cause of death worldwide for both men and women, taking an estimated 17.9 million lives each year. The Cardiovascular and Metabolic (CVM) Disease Area at the Novartis Institutes for Biomedical Research (NIBR) in Cambridge, Massachusetts is committed to discovering transformative medicines to treat cardiovascular and metabolic disorders.

We are seeking a highly motivated Principal Scientist who can join our Cell Pharmacology team to work at the bench and, over time, lead exploratory efforts (target discovery and validation) as well as drug development projects that contribute to the science and treatment of Cardiovascular and Metabolic disease.

In this role, you will:

•Generate data at the bench, as well as analyze and communicate the results to the larger drug discovery and development team in which you will work. The project(s) will be in the field of Cardiovascular and Metabolic Diseases and range from target concept to IND-enabling studies.
•Focus on applying cell biological methods. Pursue an interest in, and an aptitude for, molecular biological and biochemical methods and study the effects of low molecular weight drugs, peptides, antibodies, especially siRNA.
•Lead project teams and productively collaborate across the Novartis research organization in the many disciplines required for drug development (medicinal chemistry, biologics development, safety, etc.) as well as recognize and leverage external collaboration opportunities that amplify the Department’s research.
•Develop expertise in the any of the fields of heart failure, atherosclerosis, arrhythmia, or metabolic disease.
•Learn from other members in the Department, and mentor other less experienced bench scientists.
•Successfully contribute to, and eventually lead, high-functioning research teams.
•Independently conceive ideas and reduce complex scientific concepts into practical plans for experiments that allow data-based decision-making in a timely fashion.
•Clearly communicate with and provide advice to leaders, peers, and junior colleagues.

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you’ll bring to this role:

•PhD, MD, or MD/PhD degree plus 3 years of post-doctoral training in any area of biological science relevant to drug development (ex. Molecular Biology, Biochemistry, Cell Biology, Animal Pharmacology).
•Accomplishments during academic training as demonstrated by first or last author high-quality peer-reviewed publications.
•Experience with several cell biological systems (examples may include primary cell culture and diverse cell lines; genetic manipulation such as siRNA, shRNA, CRISPR, AAV; analysis by various methods of assaying biological activity of interest, such as GPCR and other receptor-mediated signaling, ion fluxes, other functional assays). Molecular biology and biochemistry experience is preferred.
•A history of following the literature in a relevant field and interaction with colleagues outside the home institution (for example through presentations).
•The ability to interact with and learn from other members in the department, and mentor less experienced bench scientists.
•The capacity to quickly grasp new concepts, findings and techniques and focus on detail.
•Excellent verbal and written communication skills and basic computational data analyses skills.
•Creative problem-solving capabilities, with an aptitude for working in a collaborative team-oriented environment.
•Prior experience in heart failure, atherosclerosis, arrhythmia, and/or metabolic disease is preferred, but not required.

769 million. That’s how many lives our products touch. At Novartis, being there when and how it matters most for our patients and customers allows us to live our purpose and help bring maximum impact to health outcomes.

Furthering our commitment to transforming medicine for patients, Novartis is embarking on an ambitious and exciting journey to reinvent how we use technology, data and customer insights to better serve our consumer’s needs and put them on a path to better health. This includes taking bold approaches that begin with a customer-centric mindset and harness the power of today’s digital and data-driven healthcare revolution to continue to improve and extend even more people’s lives.

• Do you want to help people understand their disease and how to seek out the proper treatment for it?
• Do you want to support patients in order to achieve the best possible outcomes?
• Do you want to deliver a leading customer experience at all touchpoints?
• Do you want to be at the forefront of leveraging today’s technology advances to create tomorrow’s healthcare innovations?

We believe the answers are found when curious, adventurous, and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to utilize the power of digital and data to individualize and maximize interactions with customers. Where you’re empowered to not fear failure when taking smart risks. And most importantly, where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.

Commitment to Diversity & Inclusion:
Novartis is committed to building an outstanding, inclusive work environment and diverse team’s representative of the patients and communities we serve.

Join our Novartis Network:
If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network
CVM Disease Area
Cambridge, MA
Research & Development
Full Time
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Principal Scientist I - Cardiovascular and Metabolic Disease

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