Jul 07, 2022

Job Description

Over 900+ clinical trials validate that gene therapies are transforming the practice of medicine. As a Research Scientist II, you will have an opportunity to join the NIBR Biologics Center (NBC) and be at the cutting edge, leading the development of innovative medicines that can improve lives of patients.

What you'll be doing:
· Executing the development and optimization of new protein and nucleic acid analytical methods for the biophysical-chemical characterization of AAV based gene therapies.

· Develop and perform HPLC and UPLC assays with minimal supervision including SEC, IEX, RP.

· Develop, optimize and perform capillary electrophoresis-sodium dodecyl sulfate (CE-SDS) based methods for analysis of AAV capsid proteins and AAV genome.

· Design experiments independently, then implementing them to characterize AAV Gene Therapy Drug Substance, in-process intermediates and process related impurities.

· Independently analyzing complex scientific data and helping to interpret and plan follow up experiments with supervision.

· Documenting your experimental design, implementation, and results in an electronic laboratory notebook following good documentation practices.

· Authoring reports and presentations with supervision. Presenting experimental plans and results to internal and external multi-disciplinary audiences.

· Acting as a key point of contact for general laboratory management activities including scheduling preventative maintenance on various instruments, tracking laboratory consumables and reagents, and shipping and receiving samples

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you'll bring:
· Bachelor's in Analytical chemistry, Molecular biology, Cell biology, Biochemistry, Virology, or a related field with 6-8 years’ relevant experience or Master's with 3-5 years relevant experience or PhD with 0+ years post-graduate experience.

· Strong benchtop skills, experienced with analysis of protein biologics and genome analysis is desired. Prior experience with AAV is beneficial but not required.

· Hands-on experiences with protein analytical chemistry techniques including Liquid chromatography and Capillary electrophoresis is desired.

· Basic experience with performing LC-MS and LC-MS/MS assays/or nucleic acids is beneficial but not required.

· Familiarity with Agilent OpenLab, Wyatt Astra and Empower is desired.

· A passion for the drug discovery/development process and interested in working with new therapeutic technologies to treat rare diseases, thinking outside the box, and exploring new approaches to innovate.

· Organization, attention to detail, and an ability to work under tight timelines in a collaborative team setting.

· Excellent interpersonal and communication skills.

· Ability to troubleshoot, think critically, and support multiple projects simultaneously.

Why Novartis?
766 million lives were touched by Novartis medicines in 2021, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.
We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.
We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!
Imagine what you could do here at Novartis!

Commitment to Diversity & Inclusion:
Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

Accessibility and reasonable accommodations
The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to [email protected] call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.


Vaccine Policy: While Novartis does not require vaccination at this time, for certain Novartis sites in the US all associates and candidates may be required to either upload an image of their COVID-19 vaccine card demonstrating proof of full vaccination for COVID-19 (or other similar evidence of vaccination) or proof of a negative COVID-19 test taken by the associate or candidate within the past seven days to enter any of our sites and/or customer office or healthcare facility, as well as prior to participating in other work related off-site meetings. Employees working in customer-facing roles must adhere to and comply with customers’ (such as hospitals, physician offices, etc.) credentialing guidelines, which may require vaccination. As required by applicable law, Novartis will consider requests for reasonable accommodation for those unable to be vaccinated. This requirement is subject to applicable state and local laws and may not be applicable to employees working in certain jurisdictions. Please send accommodation requests to [email protected]
San Diego, CA
Research & Development
Full Time
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Senior Scientist II, Characterization

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