Aug 11, 2022

Job Description

60 million.
That’s how many adults in the US experience mental illness in a given year.

The Neuroscience Department with Novartis Institutes for BioMedical Research (NIBR) is dedicated to discovering and developing groundbreaking therapies for serious diseases of the nervous system. The psychiatry team is focused on applying leading edge approaches to develop new therapeutics for these psychiatric diseases. This position is an opportunity to help create and advance such life-changing therapies.

As a new Principal Scientist in the Neuroscience Psychiatry group, you will have the opportunity to reimagine medicine by developing innovative treatments that can improve lives and health of patients suffering from psychiatric disease. You will join a vibrant scientific community and collaborate with other scientists within the neuroscience division as well as across other NIBR disciplines and platforms, including genetics, therapeutic discovery, global discovery chemistry, data science, biomarker development, and translational medicine.

Your key responsibilities:

• You will identify key unmet needs in the psychiatric disease space and propose novel therapeutic solutions
• You will implement novel approaches for identifying circuit dysfunction in animal models of disease and identify therapeutic strategies
• You will initiate and lead drug discovery efforts on high-value targets, applying innovative approaches and technologies
• You will develop hit-finding and lead-optimization strategies for relevant small molecule or biologic programs
• You will lead a matrixed team of highly talented and multi-disciplinary scientists responsible for small molecule and / or biologic screening, prioritization and validation
• You will be responsible for leading the team to achieve deliverables and meet aggressive timelines


Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you’ll bring to the role:

• PhD in relevant discipline
• 2 years of relevant postdoc/industry experience in identifying and validating new targets and/or leading innovative drug discovery programs focused on central nervous system disorders
• Self-starter with a proven track record of high caliber lab research backed by a strong publication record
• Outstanding technical ability at the bench as well as a proven ability to effectively manage teams and/or collaborative interactions
• Deep expertise in cellular neurobiology and/or molecular biology and/or assay development combined with a broad understanding of disease mechanisms underlying psychiatric diseases
• Skilled in experimental design, data analysis and data interpretation
• Strong verbal and written communication skills

Desired Qualifications:
• Experience in selecting and advancing novel drug discovery approaches
• Experience in advancing programs from early pre-clinical to clinical stage
• Proactive attitude with the ability and desire to multi-task
• A results-driven mentality with a sense of urgency and commitment to the goals of our mission

Why consider Novartis?
799 million. That’s how many lives our products touched in 2019. And while we’re proud of that fact, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people’s lives?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.

Imagine what you could do at Novartis!
Cambridge, MA
Research & Development
Full Time
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Principal Scientist (Psychiatry)

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