Jul 07, 2022

Job Description

Over 900+ clinical trials validate that gene therapies are transforming the practice of medicine. You will have an opportunity to join the NIBR Biologics Center (NBC) and be at the cutting edge, leading the development of innovative medicines that can improve lives of patients.

NBC builds the biologics pipeline in collaboration with NIBR Disease Areas and Platforms via a breadth of technologies for discovery of antibody, protein and gene therapy-based therapeutics.

The Biotherapeutic Engineering and Gene Therapy (BEGT) group within NBC drives a diverse portfolio of modalities including therapeutic proteins, multi-specific antibodies, CAR-T, RNA therapeutics and rAAV. Through cell and viral engineering as well as innovative and rational protein design, the BEGT group is a global team that works collaboratively with disease area groups to broaden the use of biologics into therapeutic applications where conventional antibodies have limitations.

What you'll be doing:

As a Senior Principal Scientist part of the NBC/BEGT Next Generation AAV group in San Diego, CA, you will have an unique opportunity to be at the cutting edge of cell and gene therapy field, and lead and contribute to the development of innovative medicines for patients devastated by diseases in collaboration with partners across the global Novartis research and development network.


• Lead, oversee and/or participate in next generation AAV projects across multiple Novartis sites to enable gene therapy platform advances and novel therapeutic capabilities in close collaboration with disease area leaders and global project teams.
• Undertake and lead efforts to develop more potent, safer and tolerable AAV vectors. The mechanisms in scope include, but are not limited to, reduction of immune response, spatial/temporal regulated expression control strategies, circuit engineering, transcriptional/post-transcriptional aspects and strategies for high throughput optimization of AAV vector components.
• Enable translation from in vitro/in vivo POC studies to therapeutic disease programs for preclinical development.
• Initiate, lead and contribute to interdisciplinary research programs in a highly collaborative and matrixed manner across internal groups and with external partners.
• Experience and familiarity with neuromuscular, cardiovascular, liver, and/or lung diseases are a plus.
• Prepare reports, manuscripts and protocols, adhering to the good research practices and quality culture across NIBR. Present results at appropriate internal and external meetings and conferences.
• Other related duties as assigned.

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you'll bring:
• Advanced degree (MD and/or PhD preferred) in gene therapy, AAV virology, synthetic biology, cell biology, genomics, pharmaceutical sciences, or related field with relevant experience - Bachelor's with 12 years relevant experience or Master's with 8 or PHD with 5.
• 3 years of experience managing and mentoring direct reports including PhD level scientists.
• Experiences in AAV biology, virology, capsid engineering, transcriptional and post-transcriptional mechanisms, genetic/epigenomic/transcriptomic profiling technologies, genome engineering (e.g. CRISPR), nonviral gene therapy, sh/miRNA biology, and analytical/process development for AAV production are highly desired.
• The position requires ability to work collaboratively across a dynamic and collaborative scientific and development environment. Therefore adaptability to emerging project/group needs, excellent communication skills, both written and verbal, and strong interpersonal skills are required.
• Strong publication, patent and/or external presentation record are preferred.

769 million lives were touched by Novartis medicines in 2020, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives. We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying! Imagine what you could do here at Novartis!

Accessibility and reasonable accommodations
The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to [email protected] call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

San Diego, CA
Research & Development
Full Time
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Associate Director - AAV Technology

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