347677BR
Aug 04, 2022
USA

Job Description

Over 900+ clinical trials validate that gene therapies are transforming the practice of medicine. You will have an opportunity to join the NIBR Biologics Center (NBC) and be at the cutting edge, leading the development of innovative medicines that can improve lives of patients.

NBC builds the biologics pipeline in collaboration with NIBR Disease Areas and Platforms via a breadth of technologies for discovery of antibody, protein and gene therapy-based therapeutics.

The Biotherapeutic Engineering and Gene Therapy (BEGT) group within NBC drives a diverse portfolio of modalities including therapeutic proteins, multi-specific antibodies, CAR-T, RNA therapeutics and rAAV. Through cell and viral engineering as well as innovative and rational protein design, the BEGT group is a global team that works collaboratively with disease area groups to broaden the use of biologics into therapeutic applications where conventional antibodies have limitations.

This role is responsible for executing early-stage process development with the focus on developability for early-stage AAV gene therapy pipeline portfolio as well as new platform process for existing and novel AAV capsids and cargo vectors.

What you'll be doing:

• Lead efforts to develop innovative and more cost-effective next generation AAV manufacturing platform.
• Design and execute experiments to drive innovative technology and platform evaluation for next generation capsids and cargo vectors.
• Lead and provide SME support collaboratively in operational and strategic discussion within a global team.
• Serve as an interface between Cell Line Development and upstream production team in support of developing and optimizing next generation AAV pre- packaging /packaging and producer cell lines.
• Serve as a SME to transfer knowledge and work collaboratively with Technical Research & Development team to advance pipeline programs into clinical phases.
• Provide technical support, training, and SME knowledge to assist with the development of junior staff.
• Manage multiple project workflow to ensure timely delivery.
• Prepare protocols, reports and provide high quality data and electronic notebook documentation.
• Other related duties as assigned.

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you'll bring:

• PhD in in Virology, Molecular Biology, Cell Biology, Chemical Engineering, gene therapy or related field.
• 3+ years of industry experience in cell line development for AAV and/or LV, therapeutic protein and antibody manufacture. Cell process development with experience in operating microbioreactor (e.g. ambr) and single-use small scale stirred-tank bioreactor experiments is preferred.
• Knowledge in AAV biology, virology, and host-virus interaction.
• Experience in molecular biology, flow cytometry, genome editing (e.g. CRISPR), and sh/miRNA is highly desired.
• Ability to work efficiently in a cross-functional matrix environment.
• Effective communication including presentations to convey scientific concepts to research scientists and cross-functional collaborators.
• Individual team player who demonstrates technical proficiency and creativity, collaboration with others and independent thought.
• Strong organization, problem-solving, and project management skills with attention to details.

769 million lives were touched by Novartis medicines in 2020, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives. We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying! Imagine what you could do here at Novartis!

Accessibility and reasonable accommodations
The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to [email protected] call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

https://www.novartis.com/careers/careers-research/notice-all-applicants

Vaccine Policy: While Novartis does not require vaccination at this time, for certain Novartis sites in the US all associates and candidates may be required to either upload an image of their COVID-19 vaccine card demonstrating proof of full vaccination for COVID-19 (or other similar evidence of vaccination) or proof of a negative COVID-19 test taken by the associate or candidate within the past seven days to enter any of our sites and/or customer office or healthcare facility, as well as prior to participating in other work related off-site meetings. Employees working in customer-facing roles must adhere to and comply with customers’ (such as hospitals, physician offices, etc.) credentialing guidelines, which may require vaccination. As required by applicable law, Novartis will consider requests for reasonable accommodation for those unable to be vaccinated. This requirement is subject to applicable state and local laws and may not be applicable to employees working in certain jurisdictions. Please send accommodation requests to [email protected]
NIBR
BIOTHERAPEUTIC AND ANALYTICAL TECHNOLOGIES - NIBR
USA
San Diego, CA
Research & Development
Full Time
Regular
No
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347677BR

Principal Scientist - AAV Process Development, Upstream

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