Jul 08, 2022

Job Description

6500! That’s the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients.

Applications are invited for an associate position in an Radioligand therapy (RLT) - Oncology Research laboratory that will carry out cutting-edge research in the area of radioisotope-based therapies together with leading basic research groups within NIBR. The candidate will be participating in drug discovery pharmacology activities performing in vivo pharmacology studies, utilizing a wide range of in vitro and in vivo techniques, like real-time autoradiography, IHC, small animal molecular imaging (PET/SPECT/µCT) and cell-based assays. We seek an experienced, motivated and ambitious associate wishing to continue a successful scientific career in a fast-paced drug discovery environment. The position is based at the Novartis Institutes of BioMedical Research (www.nibr.com) in Basel, Switzerland.

The ideal candidate should have a strong hands-on background in in vivo pharmacology, including biodistribution and efficacy evaluation, immunohistochemistry and the molecular imaging modalities, such as PET and SPECT. The successful candidate will perform independent experimentation and data analysis and have solid expertise with rodent in vivo models and is expected to play a key role in the establishment of novel rodent models for Radio Ligand Therapies in the field of cancer.

Responsibilities to include but are not limited to:
• Perform biodistribution studies and metabolites analysis for novel RLT drug candidates in rodent oncology models
• Perform pre-clinical imaging studies including PET/SPECT/uCT
• Complete in vitro characterization (e.g. plasma stability, protein binding, cellular uptake)
• Independently perform and interpret experiments under the leadership of a Lab Head
• Propose experimental alternatives, explore and introduce novel technologies and approaches
• Use literature and apply it practically
• Closely work with multiple teams across expertise groups within Oncology (Target Identification and Validation, Drug Discovery Biology, Cellular Assays, Enzymology and Biochemistry, Pharmacology)
• Consolidate, report data and present in context as needed
• Efficiently manage and maintain a functional laboratory, technical equipment and tools

Diversity & Inclusion / EEO

Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

Minimum Requirements

What you will bring to the role

• MSc or BSc (apprenticeship/vocational training) in medical physics, bioengineering, biotechnology, pharmacology or related field
• Proficiency and hands-on experience with rodent handling, including oncology models.
• Practical work experience in biomedical research from an industry or academic laboratory
• Advanced/Fluent English oral and written
Desired qualification
• Experience with PET/SPECT/uCT imaging with mice and rats
• Basic understanding of experimental design, data analysis and interpretation of imaging data
• Experience in cellular and molecular biological methods (in particular cell culture, cell viability assays, transient/stable cell line generation, immunoblotting, ELISA)
• Experience with immunohistochemical analysis, tissue processing and sectioning
• Used to successfully work within a high productivity and quality environment
• Proven ability to effectively collaborate in an interdisciplinary team environment and across sites
• Highly collaborative and self-motivated team player
• Excellent organizational and communication skills

Why Novartis?

769 million lives were touched by Novartis medicines in 2020, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.

We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!

Imagine what you could do here at Novartis!

* Some restrictions on flexible working options may apply and will be discussed during interview if applicable.

Join our Novartis Network:

If this role is not suitable to your experience or career goals but you wish to stay connected to learn more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network
Oncology NIBR
Research & Development
Full Time
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Research Scientist - Pre-clinical molecular imaging (80-100%*)

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