Jun 16, 2022

Job Description

38! Soluble Biomarkers contributed to advance science in 8 First In Human and >10 Proof of Concept studies. Data contributed to demonstrate pathway engagement, proof of biology and identify the right drug and the optimal dose for the right patient! 25 innovative soluble biomarker methods were developed in >5 disease relevant tissues. 1 purpose...to reimagine medicine!

This is an exciting opportunity to join the Molecular & Cellular Sciences (MCS) team within Biomarker Development (BMD) and Translational Medicine (TM) at the Novartis Institutes for Biomedical Research (NIBR). BMD focuses on delivering fit for purpose integrated biomarkers leveraging diverse expertise and knowledge in immunology, genomics, protein and cellular biology and state of the art data sciences.

Our innovative spirit enables the development and application of cutting-edge technologies which address key clinical questions such as target engagement, defining disease stage or progression, predict the safety or efficacy of medication, select a group of patients who would benefit most from a given therapy, and identify additional clinical indications suitable for a innovative molecule.

As a Senior Scientist within MCS in BMD, you will work in close collaboration with project and clinical teams to develop novel exploratory assays in our state of the art laboratories, implement internal and external biomarker activities and interpret results to enable proof of mechanism, proof of biology, safety and efficacy understanding. As a soluble biomarker assay expert, you will be developing and validating innovative biomarker solutions implementing new methodologies, delivering high quality data and playing a pivotal role in human clinical trials.

Your responsibilities will include, but not limited to:
•Development and validation of soluble biomarker assays with special focus on ligand binding assays (ELISA, MSD, Luminex) and other state of the art technologies.
•Implementation (sample measurement and data transfer) of validated biomarker assays in clinical studies.
•Generate and interpret data to enable proof of mechanism, dose selection & proof of biology across early clinical programs and present results at internal meetings
•Providing subject matter expertise to transition, implement and monitor assay development and validation at CROs
•Ensuring quality and timely delivery of data generated through outsourced activities
•Empowered for experimental design, execution, interpretation and reporting (oral and written) of assigned projects under Unbossed culture.
•Contributing to write quality reports and laboratory manuals.
•Cross training on a variety of biomarker modalities and technologies

Our Expectations
•Develop and validate fit-for-purpose soluble biomarker solutions
•Independently design, execute, and interpret experiments
•Ensure high quality and timely delivery of internal and external results
•Providing subject matter expertise for transferring, implementation and monitoring of soluble biomarker assay development, validation and sample analysis at external provider

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you will bring to the role:
•BS/MS degree in Biology, Immunology, Cell biology or equivalent with wide experience as a laboratory technician with 5+ year in the pharmaceutical or biotechnology environment
•Extensive understanding, knowledge and practical experience in ligand binding assays are essential, and experience on Mass spectrometry and other related technologies will be a plus.
•Analytical thinking, willingness to accept responsibility, and teamwork skills
•Experience working in a global organization and matrix-resourcing model
•Strong Computer skills (Excel, Word, PowerPoint, Soft MaxPro, SMART Book, GraphPad Prism, Watson LIMS)
•Understanding of regulatory requirement relevant to Biomarker Development (e.g. GCLP, ICH)

Why Novartis?

766 million lives were touched by Novartis medicines in 2021, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.

We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!

Imagine what you could do here at Novartis!

Commitment to Diversity & Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

Accessibility and Reasonable Accommodations: Individuals in need of a reasonable accommodation due to a medical condition or disability for any part of the application process, or to perform the essential functions of a position, please send an e-mail to [email protected] or call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Vaccine Policy: While Novartis does not require vaccination at this time, for certain Novartis sites in the US all associates and candidates may be required to either upload an image of their COVID-19 vaccine card demonstrating proof of full vaccination for COVID-19 (or other similar evidence of vaccination) or proof of a negative COVID-19 test taken by the associate or candidate within the past seven days to enter any of our sites and/or customer office or healthcare facility, as well as prior to participating in other work related off-site meetings. Employees working in customer-facing roles must adhere to and comply with customers’ (such as hospitals, physician offices, etc.) credentialing guidelines, which may require vaccination. As required by applicable law, Novartis will consider requests for reasonable accommodation for those unable to be vaccinated. This requirement is subject to applicable state and local laws and may not be applicable to employees working in certain jurisdictions. Please send accommodation requests to [email protected].

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network
Translational Medicine
Cambridge, MA
Research & Development
Full Time
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Senior Scientist - Biomarker Development, Translational Medicine

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