345982BR
Jun 24, 2022
USA

Job Description

More than 8 million lives are lost every year to infectious and tropical diseases. Within the Novartis Institutes for BioMedical Research (NIBR), the Novartis Institute for Tropical Diseases (NITD) situated in the San Francisco Bay Area is dedicated to finding new therapies to treat and prevent a range of noncommunicable and infectious conditions, with an emphasis on tropical diseases and viral pathogens. With full access to NIBR know-how, NITD has a highly collaborative culture and maintains close links with academic centers of excellence and a broad range of governmental, non-governmental and philanthropic organizations around the globe (e.g., Wellcome Trust, Bill & Melinda Gates Foundation, Medicines for Malaria Venture, and Drugs for Neglected Diseases Initiative). NITD is renowned for applying cutting-edge technologies to the discovery of high-quality clinical candidates for the treatment of neglected diseases.

About the position:
We are seeking a chemical biologist with relevant expertise in the target-based assay development and screening of small molecule library; and mechanistic characterization of new chemical entities using enzymatic and biophysical methods. The successful candidate will lead from the bench with design and implementation of biochemical and biophysical assays that support drug discovery. The candidate is expected to have pharma, biotech or academic drug discovery expertise to execute target-based and/or phenotypic high-throughput screening, SAR (Structure-activity relationship)-enabling assays and actively contribute to project ideas. An in-depth knowledge in enzyme kinetics and computational data analysis is a plus.

Your responsibilities:

• Design, develop, and implement biochemical target-based high-throughput screening assays and SAR-enabling drug discovery assays using diverse assay platforms to support hit identification to all the way to candidate selection
• Lead a multi-disciplinary team of scientists as project team representative or leader
• As a core project member or leader contributes to design and implementation of drug discovery flow-chart in close collaboration with other groups
• Responsible for biochemical and biophysical characterization of anti-viral or anti-parasitic small molecule inhibitors
• Interpret complex results and provide input to multidisciplinary project teams supporting discovery and early preclinical development of drug candidates
• Collaborate across disciplines to provide innovative approaches to discovery challenges
Troubleshoot assays and instrumentation
• Ensure integrity, quality, and timely delivery of data
• Communicate research strategy and results internally and externally
• Recruit, develop and manage people talent

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you will bring to the role:

• Ph.D. in relevant discipline with 2-8+ years of experience*
• Experience with small molecule assay development and screening in a pharmaceutical setting is preferred
• Demonstrated ability to critically evaluate and achieve assay robustness, reproducibility, and data quality
• Keen interest and demonstrated experience in anti-infective drug discovery
• Excellent written and verbal communication skills, with a few publications / patents
• Innovative mindset and collaborative spirit
• Positive attitude and “can-do” mentality

*level and pay commensurate with applicable experience

Why consider Novartis?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.

We are Novartis. Join us and help us reimagine medicine.

While Novartis does not require vaccination at this time, for certain Novartis sites in the US all associates and candidates may be required to either upload an image of their COVID-19 vaccine card demonstrating proof of full vaccination for COVID-19 (or other similar evidence of vaccination) or proof of a negative COVID-19 test taken by the associate or candidate within the past seven days to enter any of our sites and/or customer office or healthcare facility, as well as prior to participating in other work related off-site meetings. Employees working in customer-facing roles must adhere to and comply with customers’ (such as hospitals, physician offices, etc.) credentialing guidelines, which may require vaccination. As required by applicable law, Novartis will consider requests for reasonable accommodation for those unable to be vaccinated. This requirement is subject to applicable state and local laws and may not be applicable to employees working in certain jurisdictions. Please send accommodation requests to [email protected].
NIBR
NITD
USA
Emeryville, CA
Research & Development
Full Time
Regular
No
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345982BR

Principal Scientist Target based Drug Discovery NITD Bay Area

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